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Background: H-type tracheoesophageal fistulas (TEFs) are rare congenital malformations characterized by an abnormal connection between the trachea and esophagus in the absence of esophageal atresia. These lesions may remain undiagnosed for years due to subtle and non-specific symptoms, often resulting in chronic pulmonary complications. Delayed diagnosis can contribute to the development of long-standing inflammation and fibrosis, which significantly complicates surgical intervention.
Case Description: We present the case of a 14-year-old girl with a previously undiagnosed H-type TEF who was treated for recurrent lower respiratory tract infections since early childhood. Her condition acutely worsened with severe respiratory distress requiring hospitalization. Comprehensive imaging, including contrast-enhanced esophagography and chest computed tomography (CT), identified the presence of a congenital H-type TEF with associated chronic peritracheal and paraesophageal inflammatory changes. Surgical repair was performed via a cervical approach. Intraoperatively, significant fibrotic tissue surrounding the fistulous tract posed challenges to dissection and closure. To reinforce the primary suture line and reduce the risk of postoperative complications, a fibrinogen-thrombin-coated hemostatic patch (TachoSil) was applied. The patient recovered uneventfully and demonstrated no evidence of recurrence or airway compromise at 12-month follow-up.
Conclusions: This case highlights the importance of heightened clinical suspicion in children with persistent respiratory symptoms. In delayed TEF diagnoses, chronic inflammation should be anticipated. Adjunctive use of hemostatic sealants may enhance surgical safety and improve outcomes in complex cases.
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http://dx.doi.org/10.21037/tp-2025-72 | DOI Listing |
J Cyst Fibros
September 2025
Division of Paediatric Pulmonology; University of Cape Town, South Africa; Red Cross War Memorial Children's Hospital, Cape Town, South Africa.
Background: Cystic fibrosis (CF) is a genetic disorder that remains underrecognized across Africa, where limited diagnostic capacity, low awareness, and competing health priorities contribute to delayed or missed diagnoses [1-4]. Although increasing data suggests CF is more prevalent than previously believed in Africa, survival remains poor [1]. These challenges do not only affect people with CF (pwCF) in Africa but also have implications for global understanding of the disease, particularly among populations historically excluded from CF research and treatment advances.
View Article and Find Full Text PDFClin Med (Lond)
September 2025
Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Chapel Allerton Hospital, Leeds, UK; NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, Leeds, UK. Electronic address:
Systemic lupus erythematosus (SLE) is a life-long, complex, multi-system, autoimmune condition which can occur at any age, most commonly in female adults in their reproductive years. Diagnosis is often delayed with reported time from symptom onset to diagnosis as long as 6 years. Delayed diagnosis can result in irreversible organ damage, acute hospital admission, poor health-related outcomes and increased risk of mortality.
View Article and Find Full Text PDFInt J Surg Case Rep
September 2025
Department of Surgery, Lorestan University of Medical Sciences, Khorramabad, Iran. Electronic address:
Introduction: Gallbladder fistulas primarily connect to the duodenum (up to 83.3 % of cases) or colon (up to 24.5 %), with rare connections to other gastrointestinal organs.
View Article and Find Full Text PDFClin Neurol Neurosurg
September 2025
Department of Neuroradiology, Rockefeller Neuroscience Institute, West Virginia University, Morgantown, WV, USA. Electronic address:
Background: Chronic subdural hematoma (cSDH) is a common neurosurgical condition with a high recurrence rate following surgical evacuation. Middle meningeal artery embolization (MMAE) has emerged as an adjunctive or standalone treatment, but the optimal timing of embolization remains unclear. We evaluated whether early MMAE (≤2 days) versus delayed MMAE (3-7 days) is associated with improved clinical outcomes.
View Article and Find Full Text PDFJ Foot Ankle Res
September 2025
La Trobe Rural Health School, La Trobe University, Bendigo, Australia.
Background: Acute Charcot neuroarthropathy (CN) is a rare but serious complication of diabetes that requires timely diagnosis and evidence-based management to prevent long-term disability. In regional or rural settings, delivering evidence-based care is particularly challenging due to systemic and contextual barriers.
Objective: To explore the perceptions of patients and health professionals about assessment, diagnosis and management of acute CN in a regional Victorian health service.