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The comprehensive investigation into the distribution characteristics of internal defects across various growth areas of Nd, Gd: SrF (NGSF) crystals is presented in this paper by photothermal weak absorption, stress-induced birefringence, and laser confocal microscopy. The stress-gathering and absorption bands resulting from the accumulation of internal defects predominantly consist of fractures, empty tubes, and inclusions with impurities, as observed through SEM. Furthermore, laser-induced damage characteristics were examined to explore the mechanisms of internal defect-induced damage by a 1064 nm pulsed laser, revealing the exponential-Chapman relationship between weak absorption and laser damage threshold fluence. Based on the distribution profile of weak absorption, stress birefringence, and damage points, the damage mechanism is analyzed and attributed to the absorption of laser energy by the internal defects, further emphasizing that these internal defects are precursors to laser-induced damage.
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http://dx.doi.org/10.1364/OE.546757 | DOI Listing |
J Am Chem Soc
September 2025
Life-like Materials and Systems, University of Mainz, Duesbergweg 10-14, 55128 Mainz, Germany.
Transmembrane signaling is essential for cellular communication, yet reconstituting such mechanisms in synthetic systems remains challenging. Here, we report a simple and robust DNA-based mechanism for transmembrane signaling in synthetic cells using cholesterol-modified single-stranded DNA (Chol-ssDNA). We discovered that anchored Chol-ssDNA spontaneously flips across the membrane of giant unilamellar lipid vesicles (GUVs) in a nucleation-driven, defect-mediated process.
View Article and Find Full Text PDFAnn Med
December 2025
Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Background: Although some studies have indicated that CDK4/6 inhibitors are beneficial for the progression-free survival (PFS) and overall survival (OS) in breast cancer, evidence regarding the assessment of clinical response remains insufficient. Therefore, this study aims not only to evaluate the efficacy and safety of CDK4/6 inhibitors combined with endocrine therapy in HR(+)/HER2(-) metastatic breast cancer, but also to analyze the objective response rate (ORR) and clinical benefit rate (CBR), providing comprehensive clinical outcome insights.
Materials And Methods: A literature search was performed in PubMed, Embase, Cochrane Library, and ClinicalTrials.
ACS Appl Mater Interfaces
September 2025
School of Materials Science and Engineering, Beihang University, Beijing 100191, P. R. China.
Nanostructured cubic boron nitride (NS-cBN) has attracted significant attention due to its high hardness and excellent thermal stability, yet a systematic strategy to balance strength and toughness through atomically structural design remains elusive. Here, we integrate plasticity theory with large-scale atomistic simulations to elucidate the size-dependent roles of internal defects, i.e.
View Article and Find Full Text PDFACS Appl Mater Interfaces
September 2025
Advanced Materials Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250014, China.
Improving electrostrain in lead-free piezoelectric materials is critical for practical use. This study examines KTN crystals and employs two primary strategies to enhance their electrostrain: (1) Cu doping creates a restoring force enabling reversible domain switching. (2) Polarizing Cu:KTN crystals and applying an electric field perpendicular to the polarization direction ensure that all domains contribute to the strain.
View Article and Find Full Text PDFRMD Open
September 2025
Department of Rheumatology and Department of Internal Medicine, Ghent University Hospital, Unit for Molecular Immunology and Inflammation, Flemish Institute for Biotechnology, Inflammation Research Center, University of Ghent, Ghent, Belgium.
Objectives: To evaluate whether patients with systemic lupus erythematosus (SLE) have different nailfold videocapillaroscopy (NVC) findings compared with healthy controls (HCs) and whether there is an association between NVC abnormalities and disease activity, clinical and/or laboratory features in SLE.
Methods: This is an observational, multicentre, international, matched case-control study. 381 subjects (203 patients with SLE and 178 HCs) were enrolled from 16 centres in 10 countries.