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Dual-comb spectroscopy (DCS) has emerged as an indispensable optical technique for probing broadband optical spectra of molecular species with high resolution. To better understand the impact of phase noise in free-running DCS implementations, we investigate the effects of timing jitter and carrier-envelope phase noise on the shape of Lorentzian absorption lines extracted from single-shot interferograms. An analysis of linewidth broadening and fluctuations of the center frequency allows us to quantify the amount of optical frequency comb noise that significantly distorts absorption features. The theory validated through simulation should help predict the fidelity of dual-comb-based absorption measurements with relevance for precise molecular and atomic spectroscopy.
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http://dx.doi.org/10.1364/OE.547284 | DOI Listing |
Nat Aging
September 2025
Aging Biomarker Consortium (ABC), Beijing, China.
The global surge in the population of people 60 years and older, including that in China, challenges healthcare systems with rising age-related diseases. To address this demographic change, the Aging Biomarker Consortium (ABC) has launched the X-Age Project to develop a comprehensive aging evaluation system tailored to the Chinese population. Our goal is to identify robust biomarkers and construct composite aging clocks that capture biological age, defined as an individual's physiological and molecular state, across diverse Chinese cohorts.
View Article and Find Full Text PDFLight Sci Appl
September 2025
State Key Laboratory of Quantum Optics Technologies and Devices, Institute of Opto-Electronics, Shanxi University, 030006, Taiyuan, China.
The dominant technical noise of a free-running laser practically limits bright squeezed light generation, particularly within the MHz band. To overcome this, we develop a comprehensive theoretical model for nonclassical power stabilization, and propose a novel bright squeezed light generation scheme incorporating hybrid power noise suppression. Our approach integrates broadband passive power stabilization with nonclassical active stabilization, extending the feedback bandwidth to MHz frequencies.
View Article and Find Full Text PDFJ Natl Cancer Inst
September 2025
Department of Otolaryngology-Head and Neck Surgery, Harvard Medical School, Boston, Massachusetts, USA.
Purpose: Early detection of HPV-associated oropharyngeal cancer (HPV+OPSCC), the most common HPV cancer in the United States, could reduce disease-related morbidity and mortality, yet currently, there are no early detection tests. Circulating tumor HPV DNA (ctHPVDNA) is a sensitive and specific biomarker for HPV+OPSCC at diagnosis. It is unknown if ctHPVDNA is detectable prior to diagnosis, and thus it's potential as an early detection test.
View Article and Find Full Text PDFFolia Phoniatr Logop
September 2025
Introduction There is no definitive, comprehensive guide for diagnosing stuttering in multilingual speakers, and research suggests that monolingual-based diagnostic criteria may lead to misidentification in this population. This systematic review aimed to identify and consolidate conventional diagnostic guidelines for multilingual speakers and evaluate their validity in light of empirical evidence on stuttering and multilingualism. Method A systematic review was conducted using PubMed, Science Direct, SAGE, CINAHL, and Google Scholar using specific MESH terms (e.
View Article and Find Full Text PDFExp Brain Res
September 2025
Siena Brain Investigation and Neuromodulation Lab (Si-BIN Lab), Department of Medicine, Surgery and Neuroscience, Neurology and Clinical Neurophysiology Section, University of Siena, Siena, Italy.
Postdiction is a perceptual phenomenon where the perception of an earlier stimulus is influenced by a later one. This effect is commonly studied using the 'rabbit illusion', in which temporally regular, but spatially irregular, stimuli are perceived as equidistant. While previous research has focused on short inter-stimulus intervals (100-200 ms), the role of longer intervals, which may engage late attentional processes, remains unexplored.
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