Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Purpose: To evaluate the repeatability and reproducibility of the Dr.Noon CVD, an artificial intelligence software as a medical device that assesses cardiovascular risk from retinal photographs by providing risk scores and classifying patients into three categories: category 0 (low risk), category 1 (intermediate risk), and category 2 (high risk).
Methods: In this prospective, single-center study, participants underwent nonmydriatic fundus photography. For repeatability assessment, one examiner captured 3 consecutive images per eye. For reproducibility, a second examiner independently acquired 1 image per eye. Intraclass correlation coefficients (ICCs), within-subject standard deviations, and coefficients of variation were calculated. Differences by risk category and lens status were assessed using ANOVA and independent t tests.
Results: Overall, Dr.Noon CVD demonstrated excellent reliability, with a repeatability ICC of 0.997 (95% confidence interval [CI]: 0.996-0.998) and a reproducibility ICC of 0.999 (95% CI: 0.998-0.999). When analyzed by risk categories, repeatability, and reproducibility ICCs were 0.985 (95% CI: 0.974-0.997) and 0.995 (95% CI: 0.990-0.997) for category 0, 0.960 (95% CI: 0.918-0.983) and 0.969 (95% CI: 0.921-0.988) for category 1, and 0.965 (95% CI: 0.943-0.980) and 0.984 (95% CI: 0.971-0.992) for category 2. In terms of lens status, phakic eyes showed repeatability and reproducibility ICCs of 0.998 (95% CI: 0.996-0.998) and 0.999 (95% CI: 0.998-0.999), respectively, while pseudophakic eyes showed slightly lower but still excellent values of 0.989 (95% CI: 0.980-0.995) and 0.994 (95% CI: 0.988-0.997).
Conclusions: Dr.Noon CVD demonstrated high precision with excellent repeatability and reproducibility across all risk levels and lens statuses, supporting its reliability for cardiovascular risk screening using retinal images.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.jcjo.2025.07.008 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Comparison of 10-2 Visual Field Using Melbourne Rapid Fields Online Perimetry and Humphrey Field Analyzer.
Transl Vis Sci Technol
September 2025
Department of Ophthalmology, Kurashiki Medical Center, Kurashiki, Okayama, Japan.
Purpose: Melbourne rapid fields (MRF) online perimetry is web-based software that allows white-on-white threshold perimetry using any computer. This study assesses the perimetric outcomes of MRF10-2 protocol via laptop computer in comparison to Humphrey field analyzer (HFA).
Methods: This prospective and cross-sectional study included 91 eyes from 91 Japanese glaucoma patients.
Development and characterization of an autoresuscitation test for preclinical SUDEP models.
Epilepsia
September 2025
Department of Pharmacology and Neuroscience, Creighton University School of Medicine, Omaha, Nebraska, USA.
The rate of sudden unexpected death in epilepsy (SUDEP) is ~1 per 1000 patients each year. Terminal events reportedly involve repeated and prolonged apnea, suggesting a failure to autoresuscitate. To better understand the mechanisms and identify novel therapeutics, standardized tests to screen for autoresuscitation efficacy are needed in preclinical SUDEP.
View Article and Find Full Text PDFDual-Analyte Detection of Dopamine and Folic Acid Using a 3D Honeycomb Structured Reduced Graphene Oxide/Polypyrrole-Polyoxometalate Porous Film.
Langmuir
September 2025
School of Material Science and Chemical Engineering, Harbin University of Science and Technology, Harbin 150040, China.
Electrochemical sensors capable of detecting different types of biomolecules using a single electrode are highly desirable for simplifying analytical platforms and expanding their practical applicability. Herein, we develop a multifunctional electrochemical sensor based on a 3D honeycomb-like porous rGO/PPy-POM composite film for the independent detection of dopamine (DA) and folic acid (FA), two chemically distinct and clinically relevant biomolecules. The electrode is fabricated through a facile, low-cost, and environmentally friendly breath figure method to create a 3D porous reduced graphene oxide (rGO) framework, followed by codeposition of polypyrrole (PPy) and polyoxometalates (POMs).
View Article and Find Full Text PDFFermented Food Consumption Across European Regions: Protocol for the Development and Validation of the Web-Based Fermented Foods Frequency Questionnaire (3FQ).
JMIR Res Protoc
September 2025
Department of Food Science and Technology, Kaunas University of Technology, Kaunas, Lithuania.
Background: Fermented foods vary significantly by food substrate and regional consumption patterns. Although they are consumed worldwide, their intake and potential health benefits remain understudied. Europe, in particular, lacks specific consumption recommendations for most fermented foods.
View Article and Find Full Text PDFSkin intraneural phosphorylated α-synuclein is a highly specific biomarker for early Parkinson's disease.
Brain
September 2025
IRCCS Istituto delle Scienze Neurologiche di Bologna, UOC Clinica Neurologica, Bologna, 40139, Italy.
An early diagnosis of Parkinson's disease (PD) represents a challenge and novel accurate biomarkers are therefore urgently needed. Detection of phosphorylated α-synuclein (p-α-syn) in skin nerve fibers has shown promise as such a marker. However, its accuracy for the identification of PD among patients with early signs of parkinsonism has not been thoroughly explored.
View Article and Find Full Text PDF