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http://dx.doi.org/10.1007/s13312-025-00151-0 | DOI Listing |
Chest
September 2025
Flinders Health and Medical Research Institute/Adelaide Institute for Sleep Health, Flinders University, Bedford Park, South Australia, Australia.
Background: Hypoglossal nerve stimulation (HNS) to treat obstructive sleep apnea (OSA) currently requires placement of a cuff or 'saddle' electrode around or adjacent to the hypoglossal nerve(s). Limitations for this therapy include cost, invasiveness, and variable efficacy.
Research Question: Can HNS applied via percutaneous implantation of a linear, multi-pair electrode array restore airflow to airway narrowing and/or obstruction, and improve airway collapsibility in people with OSA?
Study Design And Methods: Participants with OSA undergoing drug induced sleep endoscopy with propofol were instrumented with an epiglottic pressure catheter, nasal mask and pneumotachograph.
J Sleep Res
September 2025
Department of Otorhinolaryngology-Head and Neck Surgery, Kansai Medical University, Hirakata, Japan.
In obstructive sleep apnea (OSA), repeated airway obstruction alters mucosal inflammation, which increases exhaled nitric oxide (NO) production in the nasal cavity. However, the underlying mechanism remains unclear. Accordingly, we aimed to examine the mechanism underlying NO production in patients with OSA.
View Article and Find Full Text PDFLancet Child Adolesc Health
October 2025
The Ritchie Centre, Hudson Institute of Medical Research, Melbourne, VIC, Australia; Monash Newborn, Monash Children's Hospital, Melbourne, VIC, Australia; Department of Paediatrics, Monash University, Melbourne, VIC, Australia.
Background: More than 85% of very preterm infants (born <32 weeks' gestation) breathe spontaneously within 1 min of birth, however, more than 60% of infants receive positive pressure ventilation. Face mask application soon after birth might suppress breathing through the trigeminal nerve reflex, causing vocal cord closure and hypoxia. We aimed to investigate whether nasal mask continuous positive airway pressure (nCPAP) would improve CPAP success, reducing the need for positive pressure ventilation and intubation at birth, compared with face mask CPAP (fCPAP).
View Article and Find Full Text PDFPulsating airflow jets delivered via nasal cannula offer a promising, comfortable, non-invasive alternative to continuous positive airway pressure (CPAP) for treating obstructive sleep apnea (OSA). However, the fluid dynamic mechanisms by which pulsatile flow influences upper airway pressure remain poorly understood in anatomically realistic geometries. This study used large eddy simulations (LES) to examine pressure and flow characteristics of pulsating nasal jets within a patient-specific upper airway model.
View Article and Find Full Text PDFJ Dent Res
September 2025
Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Severe obstructive sleep apnea (OSA) is linked to adverse cardiovascular outcomes. While continuous positive airway pressure (CPAP) is the standard treatment, mandibular advancement devices (MADs) offer an alternative. This substudy of a randomized trial compared the effectiveness of MADs versus CPAP on 24-h ambulatory blood pressure (BP), sleep-related quality of life, myocardial remodeling, ambulatory heart rhythm, and biomarkers in severe OSA.
View Article and Find Full Text PDF