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Random phase errors in silicon-photonic-based OPA (optical phased array) chips can significantly affect their output beam quality, making efficient phase error correction an important requirement for Lidar systems utilizing OPA chip technology. We report an improved ASPGD algorithm for performing OPA random phase error correction with high efficiency and accuracy, especially for large channel count designs. We successfully demonstrated the ASPGD algorithm phase error calibration capability using a fabricated 16-channel chip, and we also showed that the ASPGD algorithm has significantly faster convergence and higher cosine similarity values for the corrected output beam profile compared with traditional SPGD and genetic algorithms, especially for higher channel count OPA chip designs. We believe our work can make an important contribution to the field deployment of OPA technology for chip scale long-range Lidar applications.
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http://dx.doi.org/10.1364/AO.541168 | DOI Listing |
IEEE Trans Med Imaging
September 2025
Intravoxel Incoherent Motion (IVIM) MRI is a contrast-agent-free microvascular imaging method finding increasing use in biomedicine. However, there is uncertainty in the ability of IVIM-MRI to quantify tissue microvasculature given MRI's limited spatial resolution (mm scale). Nine NRG mice were subcutaneously inoculated with human pancreatic cancer BxPC-3 cells transfected with DsRed, and MR-compatible plastic window chambers were surgically installed in the dorsal skinfold.
View Article and Find Full Text PDFiScience
September 2025
College of Electronic Science and Technology, National University of Defense Technology, Changsha 410073, China.
Monopulse radar angle measurement technology is crucial for modern missile precision guidance systems due to its high accuracy and real-time capabilities. Cross-eye jamming (CEJ) is recognized as one of the most effective countermeasures against monopulse radar. However, traditional CEJ implementation requires complex amplitude and phase modulation through specialized hardware.
View Article and Find Full Text PDFJGH Open
September 2025
Department of Genomic Medicine, Division of Biochemistry, Molecular Biology, and Nutrition University Hospital of Nancy Nancy France.
Introduction: Cirrhosis progresses from compensated to decompensated phases, often marked by portal hypertension and complications like ascites, variceal hemorrhage, and hepatic encephalopathy. The ammonia-to-urea (A-to-U) ratio, reflecting urea cycle efficiency, may offer superior diagnostic performance compared to plasma ammonia levels alone. This study compared the diagnostic accuracy of the A-to-U ratio and plasma ammonia levels for identifying portal hypertension.
View Article and Find Full Text PDFBMC Ecol Evol
September 2025
Lehrstuhl für Zoologie, TUM School of Life Sciences, Technical University of Munich, Liesel-Beckmann Strasse 4, Freising, 85354, Germany.
Accurate three-dimensional localisation of ultrasonic bat calls is essential for advancing behavioural and ecological research. I present a comprehensive, open-source simulation framework-Array WAH-for designing, evaluating, and optimising microphone arrays tailored to bioacoustic tracking. The tool incorporates biologically realistic signal generation, frequency-dependent propagation, and advanced Time Difference of Arrival (TDoA) localisation algorithms, enabling precise quantification of both positional and angular accuracy.
View Article and Find Full Text PDFEur J Pharm Biopharm
September 2025
Center of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing 210009, China. Electronic address:
Prodrugs with enzymatic activation requirements, such as the weakly basic biopharmaceutical classification system (BCS) class IV compound abiraterone acetate (ABA), face considerable bioequivalence (BE) risks owing to their pH-dependent solubility, food effects, and variable intestinal hydrolysis. This study established clinically relevant dissolution specifications for ABA using biorelevant dissolution and physiologically based biopharmaceutics modelling (PBBM). Two dissolution methods, two-stage (gastrointestinal transfer simulation) and single-phase (biorelevant media), were evaluated under fasted and fed conditions.
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