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http://dx.doi.org/10.1007/s10142-025-01681-3 | DOI Listing |
Pulm Ther
September 2025
Boehringer Ingelheim Pharma GmbH & Co. KG, Binger Straße 173, 55216, Ingelheim am Rhein, Germany.
Introduction: The modification of an inhaler's air flow resistance influences a patient's inhalation flow profile, thereby affecting the exit velocity of an aerosol leaving the Respimat® mouthpiece. A slower inhalation maneuver results in reduced plume velocity and thus a decreased oropharyngeal deposition due to reduced impaction. This could not only lead to fewer unwanted side effects associated with inhaled therapies, but also enhance lung deposition.
View Article and Find Full Text PDFBMJ Open
September 2025
Upstream Lab, MAP Centre for Urban Health Solutions, Li Ka Shing Knowledge Institute, Unity Health Toronto, Toronto, Ontario, Canada
Objective: This study validates the previously tested Screening for Poverty And Related social determinants to improve Knowledge of and access to resources ('SPARK Tool') against comparison questions from well-established national surveys (Post Survey Questionnaire (PSQ)) to inform the development of a standardised tool to collect patients' demographic and social needs data in healthcare.
Design: Cross-sectional study.
Setting: Pan-Canadian study of participants from four Canadian provinces (SK, MB, ON and NL).
J Endod
September 2025
Dental Specialty Center, Brazilian Military Police, Minas Gerais, Brazil.
Introduction: To evaluate how stepwise enlargement in the mesial root canals of mandibular first molars affect shaping outcomes and irrigant dynamics.
Methods: The shaping ability and irrigant flow patterns in mesial canals of mandibular first molars enlarged with ProTaper Next instruments (25/.06v, 30/.
Behav Brain Res
September 2025
Faculty of Human Sciences, Waseda University, 2‑579‑15 Mikajima, Tokorozawa, Saitama, Japan. Electronic address:
Insight problem solving involves overcoming an impasse when a solution seems unreachable, often experienced as an 'Aha!' moment. In such solving, shifting from an incorrect representation imposed by constraints to a correct representation through constraint relaxation is critical. Prior research compared brain activity when constraint relaxation and representation change occurred versus when they did not occur, but neural activity before and after such changes within trials has remained underexplored.
View Article and Find Full Text PDFBiomol Biomed
September 2025
Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China.
Coronary heart disease (CHD) is a leading cause of morbidity and mortality; patients with type 2 diabetes mellitus (T2DM) are at particularly high risk, highlighting the need for reliable biomarkers for early detection and risk stratification. We investigated whether combining the stress hyperglycemia ratio (SHR) and systemic inflammation response index (SIRI) improves CHD detection in T2DM. In this retrospective cohort of 943 T2DM patients undergoing coronary angiography, associations of SHR and SIRI with CHD were evaluated using multivariable logistic regression and restricted cubic splines; robustness was examined with subgroup and sensitivity analyses.
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