Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Purpose: Driven equilibrium single pulse observation of T1 (DESPOT1) is a reliable technique for clinical 3D T1 brain mapping. However, its fixed repetition time (TR) and bandwidth (BW) and its linear modeling to estimate T1 conveys to an inefficient imaging protocol. We propose a variable DESPOT1 (vDESPOT1) acquisition and modeling strategy to improve scan efficiency and to accelerate image acquisition.
Methods: vDESPOT1 uses SPGR acquisitions with optimized combinations of TRs, BWs, and FAs, coupled with dictionary-based reconstruction to achieve faster acquisition and more efficient T1 mapping. The proposed vDESPOT1 method was compared to DESPOT1 and inversion recovery spin echo (IR-SE) in phantom and in ten brain healthy subjects.
Results: Results demonstrate a reduction in scan time of approximately 40 %, allowing faster 3D brain T1 mapping while maintaining accuracy and T1NR in comparison to conventional DESPOT1. Also, the computational efficiency of a pre-computed dictionary of vDESPOT1 reduces the reconstruction time by ∼50× in comparison linear regression of conventional DESPOT1. Variable BW can enhance scan efficiency without significantly affecting the SNR for T1 when using vDESPOT1.
Conclusion: These time improvements make vDESPOT1 particularly valuable for dynamic and high-field MRI applications, such as thermal therapy monitoring, pharmacokinetic analysis in DCE-MRI, and imaging in anatomies prone to motion, including the heart, liver, and lungs.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.mri.2025.110487 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The Solve-RD Solvathons as a pan-European interdisciplinary collaboration to diagnose patients with rare disease.
Nat Genet
September 2025
Institute of Medical Genetics and Applied Genomics, University of Tübingen, Tübingen, Germany.
Despite advances in genomic diagnostics, the majority of individuals with rare diseases remain without a confirmed genetic diagnosis. The rapid emergence of advanced omics technologies, such as long-read genome sequencing, optical genome mapping and multiomic profiling, has improved diagnostic yield but also substantially increased analytical and interpretational complexity. Addressing this complexity requires systematic multidisciplinary collaboration, as recently demonstrated by targeted diagnostic workshops.
View Article and Find Full Text PDFLocal activity alterations in individuals with autism correlate with neurotransmitter properties and ketamine-induced brain changes.
Nat Commun
September 2025
Institute of Neurosciences and Medicine, Brain & Behaviour (INM-7), Research Centre Juelich; Wilhelm-Johnen-Straße 1, Juelich, Germany.
Autism is a neurodevelopmental condition associated with altered resting-state brain function. An increased excitation-inhibition ratio is discussed as a pathomechanism but in-vivo evidence of disturbed neurotransmission underlying functional alterations remains scarce. We compare local resting-state brain activity and neurotransmitter co-localizations between autism (N = 405, N = 395) and neurotypical controls (N = 473, N = 474) in two independent cohorts and correlate them with excitation-inhibition changes induced by glutamatergic (ketamine) and GABAergic (midazolam) medication.
View Article and Find Full Text PDFAnatomical circuits for flexible spatial mapping by single neurons in posterior parietal cortex.
Commun Biol
September 2025
Department of Physiology Anatomy and Genetics, University of Oxford, Oxford, UK.
Primate lateral intraparietal area (LIP) has been directly linked to perceptual categorization and decision-making. However, the intrinsic LIP circuitry that gives rise to the flexible generation of motor responses to sensory instruction remains unclear. Using retrograde tracers, we delineate two distinct operational compartments based on different intrinsic connectivity patterns of dorsal and ventral LIP.
View Article and Find Full Text PDFRacial stereotypes bias the neural representation of objects towards perceived weapons.
Nat Commun
September 2025
Columbia University, Department of Psychology, New York, NY, USA.
Racial stereotypes have been shown to bias the identification of innocuous objects, making objects like wallets or tools more likely to be identified as weapons when encountered in the presence of Black individuals. One mechanism that may contribute to these biased identifications is a transient perceptual distortion driven by racial stereotypes. Here we provide neuroimaging evidence that a bias in visual representation due to automatically activated racial stereotypes may be a mechanism underlying this phenomenon.
View Article and Find Full Text PDFThe lifespan trajectories of brain activities related to conflict-driven cognitive control.
Sci Bull (Beijing)
August 2025
Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China; Department of Psychology, University of Chinese Academy of Sciences, Beijing 101408, China.
Cognitive control is fundamental to human goal-directed behavior. Understanding its trajectory across the lifespan is crucial for optimizing cognitive function throughout life, particularly during periods of rapid development and decline. While existing studies have revealed an inverted U-shaped trajectory of cognitive control in both behavioral and anatomical domains, the age-related changes in functional brain activities remain poorly understood.
View Article and Find Full Text PDF