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Multimodal emotion recognition has emerged as a promising direction for capturing the complexity of human affective states by integrating physiological and behavioral signals. However, challenges remain in addressing feature redundancy, modality heterogeneity, and insufficient inter-modal supervision. In this paper, we propose a novel Multimodal Disentangled Knowledge Distillation framework that explicitly disentangles modality-shared and modality-specific features and enhances cross-modal knowledge transfer via a graph-based distillation module. Specifically, we introduce a dual-stream representation learning architecture that separates common and unique subspaces across modalities. To facilitate effective information interaction, we design a directed and learnable modality graph, where each edge represents the semantic transfer strength from one modality to another. We validate our method on two benchmark datasets-MAHNOB-HCI and DEAP-for both regression and classification tasks, under subject-dependent and subject-independent protocols. Experimental results demonstrate that our method achieves state-of-the-art performance, with statistical significance confirmed by paired two-tailed $t$-tests. In addition, qualitative analysis of the learned modality graph and t-SNE embeddings further illustrates the effectiveness of our feature disentanglement and dynamic knowledge transfer design. This work offers a unified, interpretable, and robust framework for multimodal emotion understanding and lays the foundation for affective computing in real-world human-machine interaction scenarios.
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http://dx.doi.org/10.1109/JBHI.2025.3597398 | DOI Listing |
AAPS J
September 2025
Gene Transfer and Immunogenicity Branch, Division of Gene Therapy 2, Office of Gene Therapy, Office of Therapeutic Products, Center for Biologics Evaluation and Research, US Food and Drug Administration, WO52 RM3124, 10903 New Hampshire Ave, Silver Spring, Maryland, 20993-0002, USA.
As the field of gene therapy advances and as the importance of sex as a biological variable in shaping viral immune responses is recognized, the impact of sex on adeno-associated virus (AAV) vectors mediated gene therapies remain largely unexplored. Here we review current understanding of the immune response against AAV gene therapy as well as the knowledge of sex differences observed in viral responses. We discuss sex differences in innate immune mechanisms such as Toll-like receptor recognition and complement activation, as well as the functional responses of key immune cells such as dendritic cells, macrophages, and T/B cells that are involved in AAV immunogenicity.
View Article and Find Full Text PDFBMJ Open
September 2025
Erasmus Universiteit Rotterdam, Erasmus School of Health Policy and Management, Rotterdam, The Netherlands.
Introduction: Non-communicable diseases (NCDs) are a leading cause of global mortality, disproportionately affecting low and middle-income countries (LMICs). Physical inactivity, a key contributor to NCDs, is prevalent worldwide despite evidence supporting the health benefits of physical activity (PA). Cities, while often associated with barriers to PA, also present unique opportunities to enhance PA through systemic, context-sensitive interventions or so-called actions.
View Article and Find Full Text PDFCardiol Rev
September 2025
Department of Medicine, New York Medical College, Valhalla, NY.
Atrial fibrillation (AF) is a prevalent and complex cardiac arrhythmia requiring multifaceted management strategies. This review explores the integration of large language models (LLMs) and machine learning into AF care, with a focus on clinical utility, privacy preservation, and ethical deployment. Federated and transfer learning methods have enabled high-performance predictive modeling across distributed datasets without compromising data security.
View Article and Find Full Text PDFNeural Netw
September 2025
School of Computer Science, South China Normal University, Guangzhou, 510631, Guangdong, China; School of Artificial Intelligence, South China Normal University, Foshan, 528225, Guangdong, China. Electronic address:
Data-Free Knowledge Distillation (DFKD) have achieved significant breakthroughs, enabling the effective transfer of knowledge from teacher neural networks to student neural networks without reliance on original data. However, a significant challenge faced by existing methods that attempt to generate samples from random noise is that the noise lacks meaningful information, such as class-specific semantic information. Consequently, the absence of meaningful information makes it difficult for the generator to map this noise to the ground-truth data distribution, resulting in the generation of low-quality training samples.
View Article and Find Full Text PDFSoc Sci Med
September 2025
Lawrence Bloomberg Faculty of Nursing, University of Toronto, Toronto, Ontario, Canada. Electronic address:
Representatives of the medical device industry are routinely present in hospitals to provide education and support related to their products which, collectively, represent a company's knowledge management strategy. Between 2021 and 2022, I undertook an interpretive, phenomenological qualitative study at a large, urban, academic medical centre in Canada to examine industry's role in practice-based education. I conducted interviews (n = 23) and focus groups (N = 2) with 36 participants working across departments in roles spanning the point-of-care to executive leadership.
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