Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Objectives: To study the effect of Sheng Xuexiaoban capsules (SXXCs) on restoring immune dysfunction in ITP model mice.
Methods: We assessed changes in platelet counts, megakaryocyte counts, Treg functions, interleukin-2 expression, and other indicators to investigate the effect of SXXCs in the ITP mouse model.
Results: After treatment of the ITP mouse model with SXXCs, we found increases in platelets (577.35 ± 76.94 vs. 123.33 ± 16.24, < 0.05) and the Treg number (7.35 ± 1.94 vs. 1.33 ± 1.24), and Foxp3 mRNA expression (2: 0.2493 ± 0.03102 vs. 0.683 ± 0.05774, = 0.0027). Decreased interleukin-2 produced by effector T cells was detected (2: 0.6119 ± 0.01173 vs. 2.838 ± 0.1004, < 0.001). SXXCs treatment significantly improved the proportion and function of Tregs. By increasing Foxp3 mRNA expression and decreasing interleukin-2, we restored immune tolerance to achieve a good therapeutic effect in ITP model mice.
Conclusions: We confirmed that SXXCs have a good therapeutic effect on ITP. Simultaneously we verified the important role of Tregs in ITP pathogenesis.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12333745 | PMC |
| http://dx.doi.org/10.1097/MS9.0000000000003572 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Ribo-ITP expands the translatome of limited input samples.
bioRxiv
August 2025
Department of Molecular Biosciences, University of Texas at Austin, Austin, Texas 78712, USA.
In the last decade, an unexpectedly large number of translated regions (translons) have been discovered using ribosome profiling and proteomics. Translons can regulate mRNA translation and encode micropeptides that contribute to multiprotein complex formation, Ca regulation in muscle, and signaling during embryonic development. However, identification of translons has been limited to cell lines or large organs due to high input requirements for conventional ribosome profiling and mass spectrometry.
View Article and Find Full Text PDFIdentification of potential biomarkers for the study of the mechanisms of immune thrombocytopenia using bioinformatics and metabolomics.
Biochem Biophys Res Commun
September 2025
Inner Mongolia Academy of Traditional Chinese and Mongolian Medicine, Hohhot, 010010, China. Electronic address:
This study integrates bioinformatics and metabolomics methodologies to identify potential biomarkers and elucidate the pathogenesis of immune thrombocytopenia (ITP). Analysis of the ITP patient gene expression dataset (GSE112278) obtained from the GEO database identified 472 differentially expressed genes (DEGs), comprising 116 upregulated and 358 downregulated genes. Functional enrichment analysis revealed that these DEGs are predominantly associated with nucleotide metabolism and bile secretion pathways.
View Article and Find Full Text PDFEffect of Sheng Xuexiaoban capsules on Tregs in an ITP mouse model.
Ann Med Surg (Lond)
August 2025
Department of Haematology, The Second Hospital of Shandong University, Cheeloo College of Medicine, Shandong University, Jinan, China.
Objectives: To study the effect of Sheng Xuexiaoban capsules (SXXCs) on restoring immune dysfunction in ITP model mice.
Methods: We assessed changes in platelet counts, megakaryocyte counts, Treg functions, interleukin-2 expression, and other indicators to investigate the effect of SXXCs in the ITP mouse model.
Results: After treatment of the ITP mouse model with SXXCs, we found increases in platelets (577.
Synthesis and Biological Evaluation of Small Molecule Inhibitors of Immune Cytopenias.
ACS Omega
August 2025
Krembil Research Institute, University Health Network, 5-356 PMCRT/MaRS, 101 College Street, Toronto, Ontario M5G 2L7, Canada.
Immune cytopenias are a group of autoimmune disorders where patients develop autoantibodies against certain types of blood cells such as red blood cells (RBCs) or thrombocytes. We investigated small molecules as potential inhibitors of phagocytosis of blood cells that are prevalent in immune thrombocytopenia (ITP) and warm autoantibody immune hemolytic anemia (wAIHA). Upon screening a chemical library of over 13,000 compounds in silico, followed by evaluating 80 compounds in vitro as inhibitors of phagocytosis of opsonized RBCs by monocytes, we identified four hit molecules.
View Article and Find Full Text PDFIntegrating network pharmacology and experimental validation to explore the mechanism of Yiqi Ziyin in treating immune thrombocytopenia.
Sci Rep
August 2025
Department of Hematology, The First Affiliated Hospital of Zhejiang Chinese Medical University, No.54, Youdian Road, Shangcheng District, Hangzhou, 310006, Zhejiang, China.
To investigate the mechanism and potential targets of Yiqi Ziyin (YQZY) for treating immune thrombocytopenia (ITP). Prednisone and YQZY were orally administered to ITP mice. Post-treatment, blood samples were taken to evaluate the blood picture.
View Article and Find Full Text PDF