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http://dx.doi.org/10.1111/pin.70041 | DOI Listing |
ACS Appl Mater Interfaces
September 2025
Department of Urology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.
Benign prostatic hyperplasia (BPH) presents a significant clinical challenge, with conventional therapies carrying substantial risks, including urinary retention, sexual dysfunction, and prolonged recovery. To address the urgent need for safer, ultra-minimally invasive alternatives, we developed a sonosensitizing nanoplatform using copper-manganese-doped mesoporous silica nanoparticles (Cu-Mn@SiO) for ultrasound-induced sonodynamic therapy (SDT). Here, we demonstrate that this innovative strategy provides highly effective and precisely targeted therapy for BPH.
View Article and Find Full Text PDFInt J Surg Pathol
September 2025
Department of Pathology, Virginia Commonwealth University School of Medicine, Richmond, VA, USA.
Cystadenoma of the seminal vesicle is a benign epithelial tumor composed of variably sized cysts, lined by bland epithelial cells, and surrounded by fibromuscular stroma. Considered rare and mostly described in case reports, affected patients are frequently described as presenting with obstructive urinary symptoms due to mass effect. Nonetheless, anecdotally, we have seen these tumors present more frequently as smaller, incidental lesions.
View Article and Find Full Text PDFCureus
July 2025
Radiology, All India Institute of Medical Sciences, Deoghar, Deoghar, IND.
Extraosseous Ewing's sarcoma (EES) is a rare but aggressive soft tissue malignancy of small round blue cells and commonly poses a diagnostic challenge because of its nonspecific anatomical locations and association with other neoplasms. This series of cases presents five uncommon presentations of EES in adult patients in the form of tumors present in the mediastinum, mesentery, right suprarenal gland, infraclavicular soft tissue, and prostate. The clinical presentations varied from rapidly worsening respiratory failure caused by a mediastinal tumor to a preoperatively misdiagnosed gastrointestinal stromal tumor that was subsequently diagnosed as EES post-surgery.
View Article and Find Full Text PDFPharmaceuticals (Basel)
August 2025
Centre for Quality of Health and Living, Faculty of Health and Environmental Sciences, Central University of Technology, Bloemfontein 9300, South Africa.
Prostate cancer is the most common cancer diagnosed in men worldwide and is ranked as the fifth leading cause of cancer-related death in men globally. : We aimed to identify the effectiveness of cytotoxic plant-derived xanthones against prostate cancer over the past ten years. : Searches were performed in Google Scholar, Web of Science, Scopus and PubMed/Medline for ten years up to December 2024 using pre-defined inclusion and exclusion criteria.
View Article and Find Full Text PDFInt J Mol Sci
August 2025
Departamento de Neurobiología Celular y Molecular, Instituto de Neurobiología, Universidad Nacional Autónoma de México, Campus Juriquilla, Querétaro 76230, Mexico.
Advanced prostate cancer frequently develops resistance to antiandrogen therapy and acquires an aggressive neuroendocrine phenotype. Antiandrogens stimulate peroxisome proliferator-activated receptor gamma (PPARG) signaling and cancer progression. Molecular iodine (I) induces cytotoxic effects in prostate cancer cell lines and antineoplastic effects in neuroblastoma and breast cancer through the indirect activation of PPARG.
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