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Article Abstract
Heart failure with preserved ejection fraction (HFpEF) presents significant treatment challenges. We assessed hydrogen sulfide (HS) bioavailability in HFpEF patients and 2 animal models: the "2-hit" L-NAME + high-fat diet mouse model and ZSF1 obese rats. HS levels were significantly reduced in patients and both models, linked to decreased cystathionine-γ-lyase expression and increased sulfide quinone oxidoreductase. Cystathionine-γ-lyase knockout worsened HFpEF, whereas pharmacological supplementation with an HS donor improved diastolic function and reduced cardiac fibrosis. HS supplement synergized with GLP-1/glucagon agonist and ameliorated HFpEF. These findings suggest that enhancing HS bioavailability may provide a novel therapeutic strategy for HFpEF.
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| http://dx.doi.org/10.1016/j.jacbts.2025.04.011 | DOI Listing |
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