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http://dx.doi.org/10.1039/d5fd90030a | DOI Listing |
Angew Chem Int Ed Engl
September 2025
Institute of Pharmaceutical Science, King's College London, Franklin Wilkins Building, Stamford Street, London, SE1 9NH, UK.
As supramolecular assemblies, polypseudorotaxanes (PPR) exhibit inherent advantages in modular adaptability and structural programmability, with the potential to build tuneable platforms integrating various functionalities. Here we report the "one-pot" preparation of a self-assembled thiol-rich PPR (SPPR), where thiolated-α-cyclodextrins (SHαCD) spontaneously thread onto polymers, and are then crosslinked into a three-dimensional network by the thermally-triggered oxidation of thiols into disulfide bonds. The dynamic thiol groups along the SPPR provide remarkable modularity for the functionalization of thiophilic metal nanoparticles (NPs), exemplified by two application vectors.
View Article and Find Full Text PDFCarbohydr Polym
November 2025
Engineering Technology Research Center of Drug Carrier of Guangdong, Department of Biomedical Engineering, Jinan University, Guangzhou 510632, China; Guangdong Provincial Key Laboratory of Spine and Spinal Cord Reconstruction, The Fifth Affiliated Hospital (Heyuan Shenhe People's Hospital), Jinan Un
Recently, a variety of stimulus-responsive hydrogel platforms have been developed, specifically designed to respond to changes in physiological signals within the disease microenvironment. However, due to the restricted regulation of drug release behavior in vivo by such hydrogel systems, the precise control of drug release kinetics has not been achieved. Therefore, developing precise drug delivery platforms that enable programmable and "on-off" delivery remains a challenge in this field.
View Article and Find Full Text PDFACS Nano
September 2025
School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China.
High-dose ascorbic acid (AA) therapy induces cancer cell death primarily through its oxidized derivative, dehydroascorbic acid (DHA). However, maintaining therapeutic AA concentrations within tumors and overcoming intratumoral hypoxia pose critical barriers to the clinical application of AA. Herein, we develop an injectable supramolecular gel (αPD-1@Lv/HPAGel) composed of ascorbyl palmitate (an AA derivative), lovastatin-loaded hemoglobin nanoparticles (Lv/Hb-PDA), and the immune checkpoint inhibitor anti-PD-1 (αPD-1).
View Article and Find Full Text PDFCommun Chem
August 2025
School of Chemistry, Joseph Black Laboratories, University of Lincoln, Lincoln, LN6 7TS, UK.
Multicomponent supramolecular polymer gels are a class of soft matter materials which form via the assembly of two or more small molecules. Different structures can be generated with interesting potential functions and applications. Insight into the assembly mechanism is key in the design of these systems for specific applications.
View Article and Find Full Text PDFGels
August 2025
School of Petroleum Engineering, China University of Petroleum (East China), Qingdao 266580, China.
Traditional petroleum engineering materials have problems such as single functionality and poor environmental adaptability in terms of lost circulation control and enhanced oil recovery. Supramolecular gels, with their dynamic reversible non-covalent network structure, demonstrate unique advantages in this regard. This paper classifies supramolecular gels into hydrogen bond type, metal coordination type, host-guest type, and electrostatic interaction type based on differences in crosslinking structures.
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