Enzymatic craftsmanship in collagen glycosylation.

Nat Commun

School of Biosciences and Bioengineering, Indian Institute of Technology (IIT) Mandi, Mandi, Himachal Pradesh, India.

Published: August 2025


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Article Abstract

Collagen IV, a key structural protein of basement membranes, is vital for the development and survival of multicellular life forms. Its maturation relies on specific post-translational O- glycosylation, primarily mediated by lysyl hydroxylase-3 (LH3) and other glycosyltransferases, which sculpt collagen by modifying the hydroxylysine residues with sugar moieties.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12328614PMC
http://dx.doi.org/10.1038/s41467-025-62768-wDOI Listing

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Enzymatic craftsmanship in collagen glycosylation.

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School of Biosciences and Bioengineering, Indian Institute of Technology (IIT) Mandi, Mandi, Himachal Pradesh, India.

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