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Diet is increasingly recognized as a modifiable factor in the pathogenesis and management of inflammatory bowel disease (IBD), particularly in mild to moderate cases. While most evidence comes from pediatric studies, adult data, especially randomized controlled trials (RCTs), remain limited. Current guidelines recommend a Mediterranean diet for patients with IBD, avoiding fruits and vegetables during disease flares. Exclusive enteral nutrition (EEN) has demonstrated therapeutic potential in pediatric Crohn's disease (CD), but data in adults are less conclusive, partly due to issues with adherence. Clinicians must routinely monitor nutritional markers such as hemoglobin, iron status, vitamins, and albumin every 6-12 months, and supplement deficiencies as required. The presence of a dedicated nutrition specialist within IBD units could improve care, as nutrition also impacts psychological well-being. In addition, the role of the microbiome and how dietary interventions can modulate it to alleviate both inflammatory and functional symptoms warrant further exploration.
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http://dx.doi.org/10.1016/j.bpg.2025.101995 | DOI Listing |
Eur J Radiol
August 2025
Unità Operativa di Radiologia, ASST Fatebenefratelli Sacco, L. Sacco University Hospital, Milan, Italy. Electronic address:
Inflammatory bowel disease (IBD), including Crohn's disease (CD) and Ulcerative Colitis (UC), is characterized by chronic inflammation of the gastrointestinal tract, and its long-standing course significantly elevates the risk of colorectal cancer (CRC), primarily arising from dysplastic lesions. While regular surveillance by colonoscopy is well established for UC patients, guidelines for CD remain uncertain. Computed Tomographic Colonography (CTC) offers a minimally invasive alternative for evaluating the colon, particularly in cases where colonoscopy is incomplete or contraindicated.
View Article and Find Full Text PDFDig Dis Sci
September 2025
Department of Intensive Care Unit, Hongqi Hospital Affiliated to Mudanjiang Medical University, Mudanjiang, China.
J Mol Histol
September 2025
Department of Anatomy and Embryology, Faculty of Medicine, Cairo University, Giza, Egypt.
Cadmium (Cad) is a worldwide heavy metal pollutant associated with global health challenges. Alteration of the intestinal microbiome, due to chemicals' exposure, plays a vital role in the pathogenesis of gastrointestinal diseases such as pancreatic disorders. Hence, modulation of the gut microbiota might be a targeted approach to manage pancreatic diseases.
View Article and Find Full Text PDFAliment Pharmacol Ther
September 2025
Leeds Gastroenterology Institute, St. James's University Hospital, Leeds, UK.
HGG Adv
September 2025
Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA; Department of Biostatistics, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA. Electronic address:
Pleiotropy, the phenomenon where a genetic region confers risk to multiple traits, is widely observed, even among seemingly unrelated traits. Knowledge of pleiotropy can improve understanding of biological mechanisms of diseases/traits, and can potentially guide identification of molecular targets or help predict side-effects in drug development. However, statistical approaches for identifying pleiotropy genome-wide are limited, particularly for two correlated traits or case-control traits with unknown sample overlap or for disease traits from family studies.
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