Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
In a recent Molecular Cell study, Zhou et al. elucidated how glycogenolysis-derived glucose-1-phosphate mediates source-specific routing of glucose-6-phosphate into the pentose phosphate pathway through allosteric activation of glucose-6-phosphate dehydrogenase and liquid-liquid phase separation-mediated metabolic compartments. This compartmentalized distribution enables efficient reduced nicotinamide adenine dinucleotide phosphate (NADPH) generation from glycogenolytic flux, promoting Tm cell persistence by maintaining redox homeostasis.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.cmet.2025.07.002 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Enhancing functional properties and analysis of sugar and metabolite composition of juice through fermentation.
Food Chem X
August 2025
School of Food Science and Engineering, Key Laboratory of Food Nutrition and Functional Food of Hainan Province, Hainan University, Haikou 570228, China.
fermentation has been shown to provide significant health benefits and safety advantages. This study investigated the impact of fermentation on the physicochemical characteristics, metabolic profiles, and sensory properties of juice (HMJ). fermentation enhanced the physicochemical profile of HMJ by improving bioactive components and increasing the antioxidant activity.
View Article and Find Full Text PDFRestoring mitochondrial quantity and quality to reverse the Warburg effect and drive neuroblastoma differentiation.
Proc Natl Acad Sci U S A
September 2025
Department of Radiation Oncology, Stanford University, Stanford, CA 94305.
Reduced mitochondrial quality and quantity in tumors is associated with dedifferentiation and increased malignancy. However, it remains unclear how to restore mitochondrial quantity and quality in tumors and whether mitochondrial restoration can drive tumor differentiation. Our study shows that restoring mitochondrial function using retinoic acid (RA) to boost mitochondrial biogenesis and a mitochondrial uncoupler to enhance respiration synergistically drives neuroblastoma differentiation and inhibits proliferation.
View Article and Find Full Text PDFEffects of aging and anti-aging dietary restriction on regulators of the [NADPH]/[NADP] in different neural cell types and brain regions.
Free Radic Biol Med
September 2025
Department of Biomedical Sciences, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614. Electronic address:
Dietary restriction (DR), which slows aging, increases the ratio of reduced glutathione (GSH) to oxidized glutathione disulfide (GSSG) in the brain. DR increases liver cytoplasmic [NADPH]/[NADP] where much of the NADPH is generated by the folate cycle. This could also occur in astrocytes, the neural cell type with the highest folate cycle flux.
View Article and Find Full Text PDFFrom gut to proteomics: the impact of on post-translational modifications in colorectal cancer.
Front Oncol
August 2025
Department of Gastroenterology, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, China.
Background: Colorectal cancer (CRC) represents a significant global health challenge. Gut microbiota imbalance and abnormal chromatin modifications play critical roles in the progression of CRC. However, the mechanisms by which they exert their influences, particularly the involvement of ()-mediated post-translational modifications (PTMs), remain inadequately understood.
View Article and Find Full Text PDFThe lactylation of glucose-6-phosphate dehydrogenase promotes malignant phenotypes in cancer cell lines.
Mol Biol Rep
September 2025
Department of Scientific Management, First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230001, Anhui, China.
Background: Malignant tumors are characterized by their reliance on hyperactive glycolysis (Warburg effect), marked by increased glucose uptake, lactate secretion, and preferential glucose flux into glycolysis and the pentose phosphate pathway (PPP). These metabolic shifts provide energy, biosynthetic precursors, and maintain redox balance, supporting tumor proliferation. However, the regulatory crosstalk between glycolysis and PPP remains poorly understood.
View Article and Find Full Text PDF