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Purpose: Blood pressure (BP) response observed during exercise stress tests has been recognized as a predictor of the onset of hypertension and arterial stiffness. However, access to such testing is often limited to specialized clinical settings. The purpose of this study was to assess the utility of a simple, equipment-free exercise, self-paced spot marching exercise (SME), along with the subsequent recovery BP in evaluating vascular functions.
Patients And Methods: A cross-sectional study was conducted with 107 participants aged 40-59 years, including those with and without hypertension. During the 6-min recovery period following SME, systolic BP (SBP) and diastolic BP (DBP) were measured every 2 min. Flow-mediated dilation (FMD) and cardio-ankle vascular index (CAVI) were used to evaluate endothelial function and arterial stiffness. Pearson's correlation and multiple linear regression analyses were performed to assess the associations between recovery BP and vascular parameters.
Results: Among total participants, 4-min recovery SBP was independently associated with FMD, whereas resting BP showed no such association. CAVI was not correlated with any recovery BP. In non-hypertensive individuals, 4-min recovery SBP remained independently associated with FMD, whereas age and resting SBP were linked to CAVI.
Conclusion: These findings suggest that recovery SBP following SME reflects early endothelial dysfunction and vascular impairment. Therefore, using recovery SBP after the SME demonstrates the potential to be a tool for the early detection of vascular risk in middle-aged adults.
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http://dx.doi.org/10.2147/VHRM.S533735 | DOI Listing |
J Frailty Sarcopenia Falls
September 2025
Discipline of Medical Gerontology, School of Medicine, Trinity College Dublin, Ireland.
Phase Angle (PA), derived from bioelectrical impedance analysis, reflects cellular health and may indicate physiological resilience in ageing. We examined the relationship between PA and blood pressure (BP) recovery following an orthostatic challenge in 107 older adults attending a specialist falls clinic. Participants underwent active stand testing with continuous, beat-to-beat BP monitoring over 180 seconds.
View Article and Find Full Text PDFPharmaceuticals (Basel)
July 2025
Xi'an Key Laboratory for Research and Development of Innovative Multi-Target Antihypertensive Drugs, Xi'an Innovative Antihypertensive Drugs International Science and Technology Cooperation Base, Xi'an Medical University, Xi'an 710021, China.
: The novel compound 221s (2,9), derived from danshensu and ACEI-active proline, exhibits antihypertensive effects (50/35 mmHg SBP/DBP reduction in SHRs) with potential cough mitigation. However, its excretion kinetics remain unstudied. This study investigates 221s (2,9) elimination in rats to bridge this knowledge gap.
View Article and Find Full Text PDFGeriatrics (Basel)
July 2025
Department of Internal Medicine, Geriatrics, Amsterdam University Medical Center, Location University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.
Falls are a major public health issue among older adults, often related to postural or orthostatic hypotension (OH). The optimal timing and methods for measuring blood pressure (BP) to assess OH and its relationship with falls are uncertain. We analyzed data from two older cohorts: the PROHEALTH study ( = 30, aged ≥ 65 years) and the NILVAD-CBF trial ( = 58, aged ≥ 50 years).
View Article and Find Full Text PDFWilderness Environ Med
August 2025
Department of Emergency Medicine, All India Institute of Medical Sciences Patna, Patna, Bihar, India.
BackgroundHeat stroke represents a growing public health concern, exacerbated by rising temperatures and prolonged heat waves. This study examines the clinical profile, prognostic markers, and outcomes of heat stroke patients presenting to a tertiary care center in India and compares findings with previous global studies.ObjectiveTo analyze the clinical profile, prognostic markers, and outcomes of heat stroke patients presenting to a tertiary care center in India and to compare findings with previous global studies.
View Article and Find Full Text PDFBMC Sports Sci Med Rehabil
August 2025
Strength and Conditioning Training College, Beijing Sports University, Beijing, China.
Objective: This study aims to evaluate the efficacy of isometric resistance training (IRT) in lowering blood pressure through meta-analyses, specifically systolic blood pressure (SBP), diastolic blood pressure (DBP), and mean arterial pressure (MAP), in individuals with pre-hypertension to established hypertension. Additionally, it seeks to identify potential moderators that influence the blood pressure-lowering effects of IRT.
Methods: A systematic search was conducted in Web of Science (Core Collection), PubMed, Cochrane Library, and CNKI to identify studies employing a between-group design in individuals with pre-hypertension to established hypertension that assessed the effects of IRT on blood pressure.