Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Objective: To construct and validate a nomogram prediction model for the risk of cefoperazone sodium/sulbactam sodium (CPZ/SAM)-related coagulation disorders in hospitalized patients.
Methods: Patients treated with CPZ/SAM from January 2022 to December 2024 were enrolled and divided into a coagulation disorder group and a control group based on the occurrence of coagulation disorders. Clinical data were collected to identify risk factors and construct a nomogram model, which was validated using the Hosmer-Lemeshow goodness-of-fit test, receiver operating characteristic (ROC) curve, decision curve analysis (DCA), and clinical impact curve.
Results: A total of 439 patients were included, with 86 cases (19.59%) in the coagulation disorder group and 353 cases in the control group. Multivariate analysis identified malnutrition, recent bleeding history, prolonged treatment duration with CPZ/SAM, combination use with carbapenems, and elevated serum creatinine as independent risk factors. The constructed nomogram had an AUC of 0.845, demonstrating good calibration ability (χ²=2.312, P=0.891), providing moderate net benefit in predicting the incidence of coagulation disorders, with consistent agreement between predicted and actual probabilities.
Conclusion: The nomogram model effectively identifies high-risk patients, indicating that attention should be paid to the risk of coagulation disorders in patients with the above risk factors during CPZ/SAM treatment.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12323872 | PMC |
| http://dx.doi.org/10.2147/IDR.S534366 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The Proteomic Profiling of Circulating Extracellular Vesicles of Western Diet and Chemical-Induced Murine MASH Model.
Kaohsiung J Med Sci
September 2025
Hepatitis Research Center, College of Medicine; Center for Metabolic Disorders and Obesity; Center for Liquid Biopsy and Cohort Research, Kaohsiung Medical University, Kaohsiung, Taiwan.
Metabolic dysfunction-associated steatotic liver disease (MASLD) is an increasingly prevalent chronic liver condition that can progress to severe complications such as metabolic dysfunction-associated steatohepatitis (MASH). Despite its growing burden, there are no reliable non-invasive biomarkers for tracking disease progression. In this study, we established a murine MASLD/MASH model using a high-fat diet and chemical (CCl) induction.
View Article and Find Full Text PDFTransplantation-mediated alloimmune thrombocytopenia following liver transplantation from a donor with ITP: a case report and review of the literature.
Hematology
December 2025
Adult Hematology, Transplantation and Cellular Therapy Section, Oncology Center, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.
Objectives: To describe a rare case of transplantation-mediated alloimmune thrombocytopenia (TMAT) following liver transplantation from a donor with immune thrombocytopenia (ITP), and to contextualize findings within the literature.
Methods: We reviewed the clinical course of a 63-year-old man with hepatitis C cirrhosis and hepatocellular carcinoma who underwent orthotopic liver transplantation from a donor with severe thrombocytopenia consistent with ITP. Clinical, laboratory, and bone marrow findings were analyzed, and alternative causes of thrombocytopenia were excluded.
Wiskott-Aldrich syndrome complicated with IgG4-related Sclerosing disease: A case report and literature review.
Allergol Immunopathol (Madr)
September 2025
Division of Immunology and Allergy, Department of Internal Medicine, Ankara University School of Medicine, Ankara, Türkiye.
Wiskott-Aldrich Syndrome (WAS) is an X-linked immunodeficiency characterized by eczema, microthrombocytopenia, and recurrent infections. Immunoglobulin G4-related disease (IgG4-RD) is a fibroinflammatory disorder involving various organs. We present a 34-year-old male with WAS who developed cervical lymphadenopathy and parotid gland swelling.
View Article and Find Full Text PDFDiagnostic Performance of Prothrombin Time and Activated Partial Thromboplastin Time in Children: A Service Evaluation.
Int J Lab Hematol
September 2025
MAHSC Professor, The University of Manchester, Manchester, UK.
Background: Coagulation screening, consisting of prothrombin time (PT) and activated partial prothrombin time (aPTT), is routinely performed in paediatrics to identify bleeding disorders or guide peri-procedural management. We evaluated the trends in utilisation and diagnostic yield of PT and aPTT testing as part of coagulation screening in a tertiary paediatric centre.
Methods: All PT and aPTT samples received from June to September 2024 were analysed.
Early diagnosis and tailored treatment in atypical idiopathic thrombocytopenic purpura: A CARE compliant case report.
Medicine (Baltimore)
September 2025
Department of Pathophysiology, American University of Antigua, Osbourn, Antigua and Barbuda.
Rationale: Idiopathic thrombocytopenic purpura (ITP) is a hematological disorder characterized by a decrease in platelet count due to increased destruction or decreased production. Although the pathophysiology and etiology remain largely unknown, understanding the typical and atypical presentations of ITP is crucial for early diagnosis and effective management. This case report highlights the rationale behind a comprehensive approach for the diagnosis and treatment of ITP, especially in cases with atypical presentations.
View Article and Find Full Text PDF