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Article Abstract
The escape from flat aromatic architectures towards saturated structures enriched with an increased proportion of sp atoms (Fsp) has been harnessed as a drug design strategy. Chemical synthesis of drug-like saturated cycloalkanes, particularly in terms of the precise control of substituents either on the same or opposing faces of the ring plane, poses greater complexities than the assembly of their two-dimensional aromatic analogues. Reliable and predictable divergent synthesis of all isomers of multi-substituted cycloalkanes continues to pose a formidable challenge. Here we show a cobalt-catalysed process for achieving diastereodivergent synthesis. By strategically manipulating ligands, we accomplished diastereodivergent hydroalkylation of methylenecyclohexanes. This cobalt-catalysed system manifests exceptional resilience and versatility in synthesizing all isomers of disubstituted cyclohexanes and piperidines, as well as multi-substituted cyclohexanes, transcending inherent limited selective tendencies in other traditional synthesis strategies.
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| http://dx.doi.org/10.1038/s41557-025-01885-x | DOI Listing |
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