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The fifth international meeting, entitled "SMC Complexes: Orchestrating Diverse Genome Functions", took place in Numazu City, Shizuoka, Japan from October 15-18, 2024. With 159 attendees (115 of whom were from 18 countries and regions), the meeting aimed to further our understanding of large-scale chromosome organization and related chromosomal events, which are mediated by SMC complexes, one of the major architects of chromosomes. Discussion at the meeting was prompted by 49 talks and 82 poster presentations, which covered a variety of topics including the eukaryotic cohesin, condensin and SMC5/6 complexes, as well as bacterial and archaeal SMC complexes. Various cutting-edge approaches, ranging from molecular dynamics simulations to medical genetics, were developed and applied to reveal the functions of SMC complexes at mechanical and chromosomal levels. All attendees enjoyed the presentations of leading works and discussions with leading scientists in the field of chromosome biology.
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http://dx.doi.org/10.1111/gtc.70039 | DOI Listing |
JACC Basic Transl Sci
September 2025
BHF Centre for Cardiovascular Science, Queens Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom; Department of Pathology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Centre, Maastricht, the Netherlands. Electronic address: andy.bak
Coronary artery bypass graft (CABG) surgery remains the gold standard of care to prevent myocardial ischemia in patients with advanced atherosclerosis; however, poor long-term graft patency remains a considerable and long-standing problem. Excessive vascular smooth muscle cell (SMC) proliferation in the grafted tissue is recognized as central to late CABG failure. We previously identified SMILR, a human-specific SMC-enriched long noncoding RNA that drives SMC proliferation, suggesting that targeting SMILR expression could be a novel way to prevent neointima formation, and thus CABG failure.
View Article and Find Full Text PDFAdv Mater
September 2025
Key Laboratory of Brain-Like Neuromorphic Devices and Systems of Hebei Province, College of Electronic and Information Engineering, Hebei University, Baoding, 071002, China.
Neuromorphic Visual Devices hold considerable promise for integration into neuromorphic vision systems that combine sensing, memory, and computing. This potential arises from their synergistic benefits in optical signal detection and neuro-inspired computational processes. However, current devices face challenges such as insufficient light/dark resistance ratios, mismatched transient photo-response, and volatile retention characteristics, limiting their adaptability to complex artificial vision systems.
View Article and Find Full Text PDFBiochemistry
September 2025
Department of Molecular Nutrition, CSIR-Central Food Technological Research Institute (CFTRI), Mysuru, Karnataka 570020, India.
Chromosome organization and segregation are fundamental processes across all domains of life. In bacteria, the mechanisms governing nucleoid organization remain poorly understood. This study investigates the function of an alternative structural maintenance of chromosomes (SMC) complex, MksBEF, in .
View Article and Find Full Text PDFLiver Int
October 2025
The Global NASH Council, Washington, DC, USA.
Background: The Middle East and North Africa (MENA) region is undergoing demographic shifts potentially increasing metabolic dysfunction-associated steatotic liver disease (MASLD) and its complications. We assessed MASLD prevalence and liver disease burden from 2010 to 2021.
Methods: Data from Global Burden of Disease (GBD), United Nations Population Division and NCD Risk Factor Collaboration covering 21 MENA countries were used for annual percent change (APC) trends per Joinpoint regression.