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Lingual lymph nodes (LLN) are aberrant nodes located in the floor of mouth. Neither are metastases to these nodes routinely investigated nor are they included in the guidelines for management of tongue cancers. This article systematically collates published literature along with a meta-analysis to address clinically relevant questions pertaining to the lingual nodes. A systematic review and meta-analysis was conducted in accordance with PRISMA guidelines. Databases were searched to identify all articles on LLN in English until December 2024. A total of 24 articles were included. Proportional analysis showed an overall incidence of 8.98% (LLN metastasis). Pooled sensitivity of cross-sectional imaging to detect these nodes was 34%. Patients presenting with advanced tumour stage and/or nodal positivity have a higher risk of LLN metastasis. The analysis also showed a higher chance of recurrencein patients with metastatic LLN resulting in poorer outcomes in these tongue cancers.
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http://dx.doi.org/10.1016/j.bjoms.2025.05.017 | DOI Listing |
Head Neck
September 2025
Surgical Oncology, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi, India.
Background: Though neoadjuvant chemotherapy (NACT) has not improved survival in oral cancers, its role in tongue cancer remains uncertain.
Methods: This was a retrospective study of patients with locally advanced oral tongue cancer (Stage III-IVB) to assess response rates, mandibular preservation, and surgical extent post-NACT, along with recurrence and survival outcomes.
Results: Of 72 patients, 20 (27.
J Oral Pathol Med
September 2025
Affiliated Hospital of Chengde Medical College, Chengde, China.
Backgrounds: Head and neck cancer is among the top ten cancers worldwide, with most lesions in the oral cavity. Oral squamous cell carcinoma accounts for more than 90% of all oral malignancies and is a significant public health concern. Circular RNA and micro RNA, as non-coding RNA, plays an important role in the development of tumor transmission.
View Article and Find Full Text PDFCureus
September 2025
Department of Oral Pathology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, JPN.
Introduction Oral squamous cell carcinoma (OSCC), which is the most common cancer type in head and neck cancers, remains a serious health problem because of its high mortality. Treatment of OSCC is mainly performed with a combination of surgery and anticancer agents. However, despite the recent development of anticancer agents, the clinical outcome of OSCC has yet to be improved.
View Article and Find Full Text PDFSpec Care Dentist
September 2025
Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, São Paulo, Brazil.
Background: Hemangiolymphangioma is an uncommon benign lesion characterized by the simultaneous presence of both vascular and lymphatic vessels. It has been rarely reported, and its occurrence in the oral cavity is even rarer compared to other regions, with only 18 cases published in the English-language literature. In addition, there are doubts about the best approach.
View Article and Find Full Text PDFBr J Oral Maxillofac Surg
August 2025
Paras Cancer Centre, India. Electronic address: