Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Background: Though neoadjuvant chemotherapy (NACT) has not improved survival in oral cancers, its role in tongue cancer remains uncertain.
Methods: This was a retrospective study of patients with locally advanced oral tongue cancer (Stage III-IVB) to assess response rates, mandibular preservation, and surgical extent post-NACT, along with recurrence and survival outcomes.
Results: Of 72 patients, 20 (27.8%) received NACT, while 52 (72.2%) underwent upfront surgery. In the NACT group, 15 (75%) received TPF chemotherapy for a median of 3 cycles. One patient (5%) had a complete response, and 13 (65%) had a partial response. The clinical benefit rate was 85%. Tumor downstaging occurred in 14 (70%) patients, with 6 (42.9%) requiring less extensive surgery. The mandibular preservation rate was 75%. The pathological complete response was 10%. Local and distant control rates, disease-free survival, and overall survival were comparable.
Conclusion: Despite its retrospective design and small sample size, this study suggests that NACT can downstage tumors, improve response rates, and enable less extensive surgery in locally advanced tongue cancer.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/hed.70035 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Neoadjuvant Chemotherapy Followed by Surgery-A Promising Strategy to Reduce Morbidity in Locally Advanced Tongue Cancer.
Head Neck
September 2025
Surgical Oncology, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi, India.
Background: Though neoadjuvant chemotherapy (NACT) has not improved survival in oral cancers, its role in tongue cancer remains uncertain.
Methods: This was a retrospective study of patients with locally advanced oral tongue cancer (Stage III-IVB) to assess response rates, mandibular preservation, and surgical extent post-NACT, along with recurrence and survival outcomes.
Results: Of 72 patients, 20 (27.
The Function of Hsa_circ_0001862 Regulating miR-23a-IRF1/PPP2R5E Axis to Oral Squamous Cell Carcinoma Development.
J Oral Pathol Med
September 2025
Affiliated Hospital of Chengde Medical College, Chengde, China.
Backgrounds: Head and neck cancer is among the top ten cancers worldwide, with most lesions in the oral cavity. Oral squamous cell carcinoma accounts for more than 90% of all oral malignancies and is a significant public health concern. Circular RNA and micro RNA, as non-coding RNA, plays an important role in the development of tumor transmission.
View Article and Find Full Text PDFComparison of the Anticancer Effects of a Complementary Peptide for Dickkopf WNT Signaling Pathway Inhibitor 3 (DKK3) With Conventional Anticancer Drugs in the Treatment of Oral Squamous Cell Carcinoma: A Pilot Study.
Cureus
September 2025
Department of Oral Pathology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, JPN.
Introduction Oral squamous cell carcinoma (OSCC), which is the most common cancer type in head and neck cancers, remains a serious health problem because of its high mortality. Treatment of OSCC is mainly performed with a combination of surgery and anticancer agents. However, despite the recent development of anticancer agents, the clinical outcome of OSCC has yet to be improved.
View Article and Find Full Text PDFMultimodal Treatment Of Hemangiolymphangioma in a Pediatric Patient: Case Report and Literature Review.
Spec Care Dentist
September 2025
Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, São Paulo, Brazil.
Background: Hemangiolymphangioma is an uncommon benign lesion characterized by the simultaneous presence of both vascular and lymphatic vessels. It has been rarely reported, and its occurrence in the oral cavity is even rarer compared to other regions, with only 18 cases published in the English-language literature. In addition, there are doubts about the best approach.
View Article and Find Full Text PDFFrom Wound Coverage to Functional Healing: A Narrative Review of Biomaterial Applications in Head and Neck Mucosal Defects.
Head Neck
September 2025
Department of Oral Oncology, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan.
Background: Reconstruction of head and neck mucosal defects presents unique challenges due to the anatomical complexity and functional demands of the region. Artificial biomaterials such as collagen and polyglycolic acid (PGA) sheets have gained clinical traction owing to their ease of use and reduced surgical burden. However, limitations such as local inflammation, degradation-related complications, and mechanical instability-particularly in highly mobile areas like the tongue-continue to hinder their broader application.
View Article and Find Full Text PDF