98%
921
2 minutes
20
Objectives: To compare the efficacy of single-level and two-level deep parasternal intercostal plane (DPIP) blocks in managing postoperative pain in cardiac surgery patients undergoing median sternotomy.
Design: A prospective, randomized controlled study.
Setting: A cardiac surgery unit in a tertiary hospital, conducted under institutional ethical approval.
Participants: Adult patients (≥18 years) undergoing elective coronary artery bypass grafting (CABG), valve surgery, or combined CABG + valve procedures. Exclusion criteria included allergies to local anesthetics, emergency surgeries, reoperations, chronic pain, and major comorbidities.
Interventions: Single-level DPIP block: 10 mL of 0.25% bupivacaine bilaterally at the T4/5 intercostal space. Two-level DPIP block: 5 mL bilaterally at T2/3 and T5/6 intercostal spaces. All blocks were administered preoperatively under ultrasound guidance.
Measurements And Main Results: Both techniques provided effective analgesia. However, single-level blocks yielded significantly lower pain scores at 4, 6, and 8 hours, particularly during movement and in patients undergoing CABG. Differences decreased at 12 hours and disappeared by 24 hours. Pain scores were inversely correlated with age. No block-related complications were observed.
Conclusions: Single-level DPIP blocks demonstrated more consistent early analgesia and were technically simpler to perform. Given their efficacy, safety, and efficiency, single-level blocks may serve as a practical alternative for routine use in cardiac surgery. Further research is warranted to optimize block level, volume, and concentration based on patient and surgical characteristics.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1053/j.jvca.2025.07.008 | DOI Listing |
JCO Precis Oncol
September 2025
Cell Biology and Biotherapy Unit, Istituto Nazionale Tumori IRCCS Fondazione G. Pascale, Napoli, Italy.
Purpose: Tumor comprehensive genomic profiling (CGP) may detect potential germline pathogenic/likely pathogenic (P/LP) alterations as secondary findings. We analyzed the frequency of potentially germline variants and large rearrangements (LRs) in the RATIONAL study, an Italian multicenter, observational clinical trial that collects next-generation sequencing-based tumor profiling data, and evaluated how these findings were managed by the enrolling centers.
Patients And Methods: Patients prospectively enrolled in the pathway-B of the RATIONAL study and undergoing CGP with the FoundationOne CDx assays were included in the analysis.
Pain Med Case Rep
November 2023
Beth Israel Deaconess Medical Center, Department of Anesthesiology, Critical Care, and Pain Medicine, Harvard Medical School, Boston, MA.
Background: Spinal cord stimulation (SCS) is a minimally invasive neuromodulation treatment modality primarily indicated for failed back surgery syndrome (FBSS). When FBSS occurs in the setting of spinal cord injury (SCI) it can often be refractory to treatment with opioids and anticonvulsants; in such cases, SCS has demonstrated promising results. Here, we present a case series of 2 patients with FBSS in the setting of SCI who received pain relief with SCS therapy.
View Article and Find Full Text PDFPain Med Case Rep
October 2023
MetroHealth Medical Center, Cleveland OH.
Background: Incidental dural tear (durotomy) is a known complication of many forms of spinal instrumentation. The majority of durotomy cases are due to a known traumatic force, such as an intentional durotomy during neuraxial anesthesia, or an unintentional tear during lumbar decompression surgery. However, spontaneous dural tears have occasionally been reported.
View Article and Find Full Text PDFPain Med Case Rep
September 2023
Department of Anesthesiology and Critical Care Medicine, Division of Pain Medicine, Johns Hopkins University School of Medicine, Baltimore, MD.
Background: Many patients with severe axial lumbar pain due to the facet joints (i.e., facet arthropathy) have pain refractory to lumbar surgical instrumentation.
View Article and Find Full Text PDFJ Bras Pneumol
September 2025
. Centro de Medicina Intervencionista, Hospital Israelita Albert Einstein, São Paulo (SP) Brasil.