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http://dx.doi.org/10.1016/j.ijgc.2025.102006 | DOI Listing |
Br J Surg
September 2025
Department of Vascular Surgery, Bristol Medical School, University of Bristol, Bristol, UK.
Clin Infect Dis
September 2025
Research Department of Practice and Policy, UCL School of Pharmacy, London, United Kingdom.
Background: A subgroup analysis of the COVID-OUT trial's long-term outcome found that starting metformin within 3 days of coronavirus disease 2019 (COVID-19) diagnosis reduced post-COVID-19 condition (PCC) incidence by 63% in overweight or obese individuals. However, its generalizability remains uncertain.
Objectives: To evaluate the effectiveness of metformin in preventing PCC in adults with overweight or obesity who had a recent COVID-19 infection.
Eur Heart J Cardiovasc Pharmacother
August 2025
Unit of Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, 17177 Stockholm, Sweden.
Aims: Angiotensin-converting enzyme inhibitors (ACEi) and angiotensin receptor blockers (ARB) are effective in the long-term treatment of myocardial infarction with reduced left ventricular ejection fraction (LVEF). However, it is unknown whether there is a benefit in myocardial infarction with preserved LVEF (≥50%).
Methods And Results: We used Swedish healthcare registries to emulate a target trial of ACEi/ARBs vs.
J Biomech Eng
August 2025
National Heart and Lung Institute, Imperial College London, London W12 0NN, UK & The Alan Turing Institute, The British Library, London NW1 2DB, UK.
Cardiovascular diseases are the leading cause of death. Clinical data used to decide treatment are hard to integrate and interpret, making optimal treatment selection difficult. Personalised models can be used to integrate clinical data into a physics and physiology-constrained framework, but their clinical application faces limitations due to complex calibration and validation.
View Article and Find Full Text PDFCrit Care
August 2025
School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.
Background: The optimal transfusion threshold for patients undergoing venoarterial extracorporeal membrane oxygenation (VA-ECMO) remains uncertain.
Methods: We used data from OBLEX (ClinicalTrials.gov: NCT03714048), an international, prospective, observational study conducted across 12 centres in Australia, Europe, and North America between 2019 and 2022.