98%
921
2 minutes
20
Background: The incidence of individuals diagnosed with colorectal cancer under the age of 50, often referred to as early-onset colorectal cancer (EOCRC), has risen worldwide. The EOCRC patients have unique needs; however, there are no clear guidelines on how to address them. The objective of the present study was to propose a blueprint for EOCRC program development and implementation.
Materials And Methods: A consensual qualitative design was used to frame the present study. Seven leaders of North American EOCRC centers were invited to devise a stepwise blueprint for developing and implementing EOCRC programs. Discussions were transcribed and conceptually organized into a framework. An analysis of documents detailing and describing the services offered within each center was also conducted.
Results: The analysis was organized around 2 domains: (1) the rationale underlying the creation of EOCRC programs, and (2) the lessons learned from developing and implementing EOCRC programs. Participants agreed that as the EOCRC programs represent innovative initiatives, a program manager who closely monitors the program is core to successful implementation.
Conclusions: This study outlines a 10-step actionable guideline for developing and implementing EOCRC programs aiming at addressing the unmet needs of this growing population.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1093/oncolo/oyaf199 | DOI Listing |
Free Radic Biol Med
August 2025
Department of Environmental Health Sciences, Yale School of Public Health, 60 College Street, New Haven, CT, 06510, USA. Electronic address:
Early-onset colorectal cancer (EO-CRC) occurring in individuals under age 50 is rapidly increasing globally, while the incidence of late-onset colorectal cancer (LO-CRC) has decreased over recent years. Previous studies have identified metabolites linked to CRC biology, however tumor-specific differences between EO-CRC and LO-CRC have not been explored. This study aimed to compare the tumor metabolome of EO-CRC and LO-CRC patients to reveal the unique biochemical state of EO-CRC.
View Article and Find Full Text PDFBr J Cancer
August 2025
University of Exeter, St Luke's Campus, Exeter, UK.
Background: The incidence of early-onset colorectal cancer (EOCRC) is rising rapidly, with diagnoses typically occurring at a more advanced stage than late-onset CRC. In the absence of screening for younger patients, diagnosis relies on symptomatic presentation. The faecal immunochemical test (FIT) is a diagnostic triage tool for patients presenting with clinical features of CRC in primary care, though its performance in individuals under 50 years is not well established.
View Article and Find Full Text PDFOncologist
August 2025
Colorectal Cancer Canada, Montreal, Quebec, Canada.
Background: The incidence of individuals diagnosed with colorectal cancer under the age of 50, often referred to as early-onset colorectal cancer (EOCRC), has risen worldwide. The EOCRC patients have unique needs; however, there are no clear guidelines on how to address them. The objective of the present study was to propose a blueprint for EOCRC program development and implementation.
View Article and Find Full Text PDFFuture Oncol
August 2025
Department of Surgery and Critical Care, University of Otago Christchurch, Christchurch, New Zealand.
Background: Early-onset colorectal cancer, diagnosed before 50 years (EOCRC), is rising. Previous studies suggest younger patients experience longer diagnostic intervals potentially contributing to poorer outcomes.
Research Design And Methods: A prospective cohort study comparing EOCRC patients in Canterbury, Aotearoa New Zealand, with a control group of late-onset patients (65+ years, LOCRC).
Cancer Control
July 2025
Division of Gastroenterology, Prisma Health Midlands, Columbia, SC, USA.
IntroductionEarly-onset colorectal cancer (EOCRC) patients are more likely to have advanced diagnoses across different race/ethnicity or age at diagnosis groups. Thus, we examined the relationship of racial/ethnic disparities with cancer diagnoses (tumor features and histologic types) and 5-year causes-specific survival for EOCRC across three age-at-diagnosis groups.MethodsWe conducted a retrospective cohort analysis using the 2006-2020 Surveillance, Epidemiology, and End Results (SEER) Program, using multivariable logistic and Cox proportional hazards models to examine the association of race/ethnicity and age with survival.
View Article and Find Full Text PDF