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London's Cycle Superhighways (CS) form a network of cycle routes connecting central London to outer boroughs, introduced in 2010 to promote cycling and improve safety. This paper examines their causal impact on cycling volume and safety using detailed road traffic and road safety data from the UK's Department for Transport. To estimate these effects, we employ propensity score-matched difference-in-differences and panel outcome regression models, comparing two distinct infrastructure types: segregated and non-segregated CS. A key contribution of this study is the development of a novel safety indicator - the normalised collision rate - that accounts for changes in cyclist volume (exposure) while incorporating expected non-linearities in the relationship between collisions and exposure. Our findings indicate that non-segregated CS did not increase cycling volume but led to a substantially higher collision rate. This increase appears to be driven by a post-intervention surge in the proportion of new, inexperienced cyclists along these routes. In contrast, segregated CS effectively increased cycling volume without increasing collision rates. Further, an evaluation of a major segregation upgrade along an existing non-segregated CS route revealed a notable reduction in collision rates. These results highlight the crucial role of segregated infrastructure in not only encouraging cycling but also ensuring it remains a safe and viable urban transport option.
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http://dx.doi.org/10.1016/j.aap.2025.108168 | DOI Listing |
J Cardiovasc Pharmacol
September 2025
Graduate School of Cardiology, Bengbu Medical University, Bengbu 233000, Anhui, China.
Chronic stress-induced cardiac hypertrophy remains a critical precursor to heart failure, with current therapies limited by incomplete mechanistic targeting. Cyclin-dependent kinases (CDKs), pivotal regulators of cell cycle and stress signaling, are emerging therapeutic targets in cardiovascular pathologies. Using bioinformatics analysis of human hypertrophic cardiomyopathy datasets (GSE5500, GSE136308) and a murine transverse aortic constriction (TAC) model, we investigated the therapeutic effects of the CDK inhibitor R547 (10 mg/kg, intraperitoneal every 3 days) on pressure overload-induced cardiac remodeling.
View Article and Find Full Text PDFCancer Pathog Ther
September 2025
Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27708, United States.
Background: Stereotactic body radiotherapy (SBRT) is an effective treatment for early-stage non-small cell lung cancer. However, patient breathing can affect treatment accuracy. Therefore, this study aimed to develop a bi-polar (BP) gated motion management strategy for SBRT and evaluate its feasibility geometrically and dosimetrically.
View Article and Find Full Text PDFComput Methods Biomech Biomed Engin
September 2025
Department of Mathematics, Morgan State University, Baltimore, MD, USA.
Accurate modeling of lung parenchymal biomechanics is critical for understanding respiratory function and improving diagnoses. Traditional hyperelastic models capture tissue deformation but miss essential physiological interactions. This study evaluates an experimentally informed poroelastic model (Birzle's formulation) against hyperelastic-only models within a finite element framework.
View Article and Find Full Text PDFJ Cereb Blood Flow Metab
September 2025
iInstitut de Mécanique des Fluides de Toulouse (IMFT), Université de Toulouse, CNRS, INPT, Université Toulouse III - Paul Sabatier (UPS), Toulouse, France.
Cerebral Amyloid Angiopathy, a common age-related small vessel disease leading to hemorrhagic stroke, shares many characteristics with Alzheimer's disease: toxic amyloid deposits, microvascular alterations and enlarged perivascular spaces (EPVS). Together, PVS enlargement, reduced amyloid-β clearance and further accumulation form a vicious cycle underlying disease progression. Yet, the neuropathological correlates of EPVS, including the associated angioarchitecture, are poorly understood.
View Article and Find Full Text PDFDrug Dev Res
September 2025
Department of Pharmaceutical Chemistry, ISF College of Pharmacy, Moga, Punjab, India.
The epidermal growth factor receptor (EGFR) is a common diver gene for lung cancer (NSCLC), which leads to an increasing death rate worldwide. This study reports the design, synthesis, and biological evaluation of triazole-clubbed pyrimidine derivatives (RDa-RDm) as potential anticancer agents. Thirteen compounds were synthesized and screened against the A549 lung cancer cell line.
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