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Whether or not femto-scale droplets of quark-gluon plasma (QGP) are formed in so-called small systems at high-energy colliders is a pressing question in the phenomenology of the strong interaction. For proton-proton or proton-nucleus collisions the answer is inconclusive due to the large theoretical uncertainties plaguing the description of these processes. While upcoming data on collisions of ^{16}O nuclei may mitigate these uncertainties in the near future, here we demonstrate the unique possibilities offered by complementing ^{16}O+^{16}O data with collisions of ^{20}Ne ions. We couple both nuclear lattice effective field theory (NLEFT) and projected generator coordinate method (PGCM) ab initio descriptions of the structure of ^{20}Ne and ^{16}O to hydrodynamic simulations of ^{16}O+^{16}O and ^{20}Ne+^{20}Ne collisions at high energy. We isolate the imprints of the bowling-pin shape of ^{20}Ne on the collective flow of hadrons, which can be used to perform quantitative tests of the hydrodynamic QGP paradigm. In particular, we predict that the elliptic flow of ^{20}Ne+^{20}Ne collisions is enhanced by as much as 1.174(8)_{stat}(31)_{syst} for NLEFT and 1.139(6)_{stat}(39)_{syst} for PGCM relative to ^{16}O+^{16}O collisions for the 1% most central events. At the same time, theoretical uncertainties largely cancel when studying relative variations of observables between two systems. This demonstrates a method based on experiments with two light-ion species for precision characterizations of the collective dynamics and its emergence in a small system.
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http://dx.doi.org/10.1103/k8rb-jgvq | DOI Listing |
Genome Biol
September 2025
Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, 100101, Beijing, China.
Background: Centromeres are crucial for precise chromosome segregation and maintaining genome stability during cell division. However, their evolutionary dynamics, particularly in polyploid organisms with complex genomic architectures, remain largely enigmatic. Allopolyploid wheat, with its well-defined hierarchical ploidy series and recent polyploidization history, serves as an excellent model to explore centromere evolution.
View Article and Find Full Text PDFOdontology
September 2025
Department of Periodontics, Saveetha Dental College and Hospital, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India.
Orthodontic-induced gingival enlargement (OIGE) affects approximately 15-30% of patients undergoing orthodontic treatment and remains largely unpredictable, often relying on subjective clinical assessments made after irreversible tissue changes have occurred. S100A4 is a well-characterized marker of activated fibroblasts involved in pathological tissue remodeling. This was a cross-sectional precision biomarker study that analyzed gingival tissue samples from three groups: healthy controls (n = 60), orthodontic patients without gingival enlargement (n = 31), and patients with clinically diagnosed OIGE (n = 61).
View Article and Find Full Text PDFJ Hum Genet
September 2025
Division of Integrative Genomics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Comprehensive genomic profiling (CGP) expands treatment options for solid tumor patients and identifies hereditary cancers. However, in Japan, confirmatory tests have been conducted in only 31.6% of patients with presumed germline pathogenic variants (GPVs) detected through tumor-only testing.
View Article and Find Full Text PDFNPJ Biofilms Microbiomes
September 2025
Research Group Medical Systems Biology, University Hospital Schleswig-Holstein Campus Kiel, 24105 Kiel University, Kiel, Schleswig-Holstein, Germany.
Urinary tract infections (UTIs) are among the most common bacterial infections and are increasingly complicated by multidrug resistance (MDR). While Escherichia coli is frequently implicated, the contribution of broader microbial communities remains less understood. Here, we integrate metatranscriptomic sequencing with genome-scale metabolic modeling to characterize active metabolic functions of patient-specific urinary microbiomes during acute UTI.
View Article and Find Full Text PDFSignal Transduct Target Ther
September 2025
State Key Laboratory of Molecular Oncology & Department of Medical Oncology & Department of Pathology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Small-cell lung cancer (SCLC), an aggressive neuroendocrine tumor strongly associated with exposure to tobacco carcinogens, is characterized by early dissemination and dismal prognosis with a five-year overall survival of less than 7%. High-frequency gain-of-function mutations in oncogenes are rarely reported, and intratumor heterogeneity (ITH) remains to be determined in SCLC. Here, via multiomics analyses of 314 SCLCs, we found that the ASCL1/MKI67 and ASCL1/CRIP2 clusters accounted for 74.
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