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ST elevation in aVR on the electrocardiogram (ECG) indicates high-risk acute coronary syndrome (ACS) but is rarely reported in pulmonary embolisms (PEs). We present a 47-year-old female with a history of PE and ankylosing spondylitis admitted for chest pain, nausea, and an episode of possible collapse. Her ECG showed ST elevation in aVR with anterolateral ST depressions, prompting a normal emergency coronary angiogram. Bedside echocardiography revealed right ventricular (RV) dilatation, and lab tests showed elevated D-dimer levels and troponin. Urgent computed tomography of the pulmonary arteries (CTPA) confirmed large bilateral PEs. The patient was treated with Enoxaparin and transitioned to Warfarin, resulting in symptom improvement. ST-segment elevation in lead aVR may mimic ACS but suggests significant conditions like PE, often from RV strain and impaired coronary blood flow due to acute RV failure. Clinicians should suspect PE in patients with aVR changes, especially with relevant clinical history and signs of RV pressure overload on echocardiography, to prevent misdiagnosis and ensure timely care.
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http://dx.doi.org/10.1002/ccr3.70671 | DOI Listing |
BMC Cardiovasc Disord
September 2025
Department of Cardiology, the First People's Hospital of Yibin, Yibin, Sichuan, China.
Background: The de Winter electrocardiographic (ECG) pattern, characterized by upsloping ST-segment depression and tall T waves in leads V1-V6, is typically associated with proximal left anterior descending (LAD) artery occlusion. When combined with pronounced ST-segment elevation in lead aVR, it may indicate a more severe coronary artery involvement.
Case Presentation: A 36-year-old male smoker presented with acute chest pain for 2 h.
Perfusion
September 2025
Eskisehir Sehir Hastanesi, Eskisehir, Turkey.
ObjectiveThis study aimed to investigate the prognostic value of the preoperative Inflammatory Prognostic Index (IPI) in predicting late mortality in patients undergoing isolated surgical aortic valve replacement (AVR).MethodsA retrospective, single-center cohort of 400 patients who underwent elective, isolated surgical AVR between 2015 and 2023 was analyzed. The IPI was calculated using the formula: C-reactive protein (CRP) × neutrophil-to-lymphocyte ratio (NLR) / albumin.
View Article and Find Full Text PDFMedicina (Kaunas)
August 2025
Department of Emergency Medicine, Istanbul Sancaktepe Sehit Prof. Dr. İlhan Varank Training and Research Hospital, 34785 Istanbul, Turkey.
: Early repolarization (ER), previously considered benign for many years, is now recognized as a substantial risk factor for malignant arrhythmia, coronary artery disease, and mortality. The ER pattern, previously regarded as a benign electrocardiographic characteristic, has lately been demonstrated to have a strong association with malignant arrhythmias, coronary artery disease, and elevated death rates. This study seeks to illustrate the prognostic significance of QT interval (QTc) prolongation on electrocardiograms for acute coronary syndrome and death in emergency cases.
View Article and Find Full Text PDFGenes (Basel)
August 2025
Department of Pediatrics and Endocrinology, Medical University of Warsaw, 02-091 Warsaw, Poland.
: Diabetes insipidus (DI) in newborns is an extremely rare condition, with the age of presentation strongly suggesting a genetic background of the disease. The differential diagnosis should include arginine vasopressin deficiency (AVD) and arginine vasopressin resistance (AVR). Some novel diagnostic tools such as copeptin evaluation and genetic tests are vital for early diagnosis.
View Article and Find Full Text PDFJ Clin Med
August 2025
Faculty of Medicine and Pharmacy, University of Oradea, 410073 Oradea, Romania.
The identification of the left anterior descending (LAD) artery as the culprit vessel in ST-segment elevation myocardial infarction (STEMI) is critical for rapid decision-making and targeted reperfusion. Electrocardiography (ECG) remains a vital diagnostic tool, especially in cases of no prior clinical or imaging data. This study evaluates the accuracy of 12-lead ECG in identifying LAD involvement and occlusion level, while examining the prognostic significance of proximal versus distal LAD lesions in the era of modern reperfusion techniques.
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