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Tricuspid regurgitation (TR) is a highly prevalent valve disease, and cardiac surgery has been used in patients with severe symptomatic TR undergoing surgery for other cardiac lesions or less frequently for isolated TR. More recently, transcatheter therapies, particularly transcatheter edge-to-edge repair and valve replacement, have emerged as therapeutic alternatives in those considered at high to extreme risk for surgery. Because of the anatomical proximity of the tricuspid valve (TV) and the atrioventricular conduction system, the risk for high-degree atrioventricular block and permanent pacemaker implantation remains important, as they are common adverse events after transcatheter valve replacement. Furthermore, a significant number of these patients have cardiac implantable electronic devices with leads that may either worsen TR or complicate the treatment procedure. The aim of this review is to provide an overview of different TV interventions, focusing on the risk for atrioventricular conduction disturbances in patients without previous cardiac implantable electronic devices as well as the risk for pacemaker lead-related adverse events following transcatheter TV interventions. Finally, the authors propose a management algorithm for patients with conduction disturbances following TV intervention and for those with permanent leads undergoing transcatheter interventions.
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http://dx.doi.org/10.1016/j.jcin.2025.06.026 | DOI Listing |
JACC Case Rep
September 2025
Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
Background: Cardiac sarcoidosis (CS) usually affects the left ventricle and presents with nonspecific features like conduction abnormalities and ventricular arrhythmias. However, right ventricle (RV)-dominant involvement has been increasingly reported, making diagnosis difficult.
Case Summary: A 55-year-old man presented with palpitations.
Mol Genet Genomic Med
September 2025
Department of Maternal-Fetal Medicine, Augusta University, Augusta, Georgia, USA.
Introduction: Spinal muscular atrophy (SMA), caused by pathogenic variants in the survival motor neuron (SMN) gene, is the most common genetic cause of mortality in children under the age of two. Prior reports of obstetric sonograms performed in pregnancies with severe forms of fetal SMA have discrepant findings that may stem from a failure to account for the SMN2 copy number.
Methods: We present a neonate diagnosed with SMA type 0 postnatally (0SMN1/1SMN2 genotype).
Eur J Heart Fail
September 2025
Cardiology Department, University Medical Centre Ljubljana, Ljubljana, Slovenia.
Aims: There is a lack of data from randomized clinical trials comparing treatment outcomes between conduction system pacing (CSP) modalities and biventricular pacing (BVP) in symptomatic patients with refractory atrial fibrillation (AF) scheduled for atrioventricular node ablation (AVNA). The CONDUCT-AF investigates whether CSP is non-inferior to BVP in improving left ventricular ejection fraction (LVEF) and clinical outcomes in heart failure (HF) patients with symptomatic AF undergoing AVNA.
Methods: This study is an investigator-initiated, prospective, randomized, multicentre clinical trial conducted across 10 European centres, enrolling 82 patients with symptomatic AF, HF with reduced LVEF, and narrow QRS.
Open Access Rheumatol
August 2025
Department of Rheumatology and Immunology, the First Affiliated Hospital, Jinan University, Guangzhou, 510632, People's Republic of China.
Objective: To evaluate the efficacy of baricitinib in combination therapy for managing refractory, rapidly progressive systemic sclerosis (SSc) with severe cardiac conduction defects and interstitial lung disease (ILD).
Methods: A 48-year-old male patient with SSc complicated by significant cardiac enlargement, third-degree atrioventricular block, heart failure, progressive ILD, and partial intestinal obstruction was included in the study. Prior treatments with mycophenolate mofetil (MMF), tacrolimus, and cyclophosphamide (CTX) had shown limited efficacy.
Struct Heart
September 2025
The Carl and Edyth Lindner Research Center at the Christ Hospital, Cincinnati, Ohio, USA.
Severe, untreated tricuspid regurgitation is associated with worse clinical outcomes. While isolated tricuspid valve (TV) surgery has been linked to poor long-term outcomes, transcatheter TV therapies, including edge-to-edge repair and transcatheter tricuspid valve replacement (TTVR), have emerged as effective alternatives and have been shown to improve outcomes, leading to their regulatory approval in the United States. Conduction system abnormalities are commonly seen among patients undergoing TTVR due to the close proximity of the atrioventricular node and the His bundle to the TV annulus.
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