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Article Abstract
Obesity and metabolic diseases, such as insulin resistance and type 2 diabetes, are closely linked to different types of cancers. With obesity rates rising globally, its influence on cancer incidence and progression has become increasingly significant. The obesity-cancer axis is thought to be driven by a complex interplay of metabolic and immune factors, including adipokines, lipids, immune cells and gene regulatory mechanisms. These elements work synergistically to promote cancer initiation and progression in the context of obesity. A more precise understanding and targeting these modulators should pave the way to novel therapeutic strategies to disrupt the link between obesity and cancer, improve cancer outcomes, and reduce treatment resistance. This review provides a comprehensive analysis of these factors, many of them derived from adipose tissue, highlightning their roles in shaping the obesity-cancer axis.
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| http://dx.doi.org/10.1016/j.semcancer.2025.07.006 | DOI Listing |
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