Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Secreted protein acidic and rich in cysteine (SPARC) is expressed in diverse tissues and plays roles in various biological functions and processes. Increased serum levels of SPARC or its gene overexpression have been reported following numerous physiological and pathological changes including injuries, exercise, regeneration, obesity, cancer, and inflammation. Such expression pattern interrelation between these biological changes and the SPARC expression/secretion points to it as a biomarker. This property could lead to a variety of potential applications ranging from mechanistic studies and animal model validation to the clinical and therapeutic evaluation of both disease prognosis and pharmacological agents.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8615851 | PMC |
| http://dx.doi.org/10.3390/biom11111689 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Complement Factor I Deficiency With Acute Hemorrhagic Leukoencephalitis and Longitudinally Extensive Transverse Myelitis: A Case Report.
Neurol Neuroimmunol Neuroinflamm
November 2025
Department of Neurology, UC Davis Medical Center, Sacramento, CA.
Objectives: Complement factor I (CFI) deficiency is a rare condition that can present with fulminant relapsing CNS autoinflammation. In this report, we highlight the utility of genetic testing in unexplained CNS autoinflammation.
Methods: This case report describes a young adult with partial CFI deficiency, presenting with acute hemorrhagic leukoencephalitis and longitudinally extensive transverse myelitis.
Mechanotransduction mechanisms in human erythrocytes: Fundamental physiology and clinical significance.
Channels (Austin)
December 2025
Biorheology Research Laboratory, Faculty of Health, Griffith University, Gold Coast, Australia.
The hallmarks of mechanosensitive ion channels have been observed for half a century in various cell lines, although their mechanisms and molecular identities remained unknown until recently. Identification of the bona fide mammalian mechanosensory Piezo channels resulted in an explosion of research exploring the translation of mechanical cues into biochemical signals and dynamic cell morphology responses. One of the Piezo isoforms - Piezo1 - is integral in the erythrocyte (red blood cell; RBC) membrane.
View Article and Find Full Text PDFEvaluation of some immune mediators (IL-16, IgE and eosinophils) as diagnostic markers for COVID-19.
Pol Merkur Lekarski
September 2025
FACULTY OF NURSING, UNIVERSITY OF KUFA, KUFA, IRAQ.
Objective: Aim: To evaluate clinical applicability of immune mediator's interleukin-16, immunoglobulin E along with eosinophil count in diagnosing COVID-19 and determining its severity.
Patients And Methods: Materials and Methods: Cross-sectional case-control study was conducted at Al-Najaf General Hospital, Najaf, Iraq between March and August 2024. 120 participants: 60 confirmed COVID-19 cases and 60 healthy controls which matched cases in terms of age and sex.
The peculiarities of biochemical and morphological changes in the heart of the rats under chronic hypodynamia in the development of adrenalin damage of heart.
Pol Merkur Lekarski
September 2025
I. HORBACHEVSKY TERNOPIL NATIONAL MEDICAL UNIVERSITY, TERNOPIL, UKRAINE.
Objective: Aim: To evaluate the state of oxidation processes and morphological changes in the heart of rats with chronic hypodynamia during the development of epinephrine heart damage (EHD)..
Patients And Methods: Materials and Methods: The study was performed on 144 white male Wistar rats.
The Effect of the CBL-CIPK Signaling Pathway on Cucumber Plants Growth under High CO and Low Nitrogen Conditions.
J Agric Food Chem
September 2025
College of Horticulture and Landscape Architecture, Yangzhou University, Yangzhou 225009, China.
Rising atmospheric CO exposes plants to high-CO environments, while excessive nitrogen fertilizer use degrades soil, highlighting the need to reduce nitrogen input and cultivate vigorous cucumber seedlings under HC-LN conditions. Calcineurin B-like proteins (CBLs) sense calcium signals and regulate carbon/nitrogen metabolism via CBL-interacting protein kinases (CIPKs), though their roles in cucumber under HC-LN conditions are unclear. Here, we identified seven and 19 genes.
View Article and Find Full Text PDF