98%
921
2 minutes
20
Despite the importance of the iridocorneal angle in childhood glaucoma, relatively few studies have been published on the outflow system in children and how surgery affects the iridocorneal angle. Using overhead-mounted optical coherence tomography, we investigated the iridocorneal angle of patients with childhood glaucoma after angle surgery to describe the appearance of the angle and how it may be associated with intraocular pressure (IOP) control. No eyes showed closed angle or peripheral anterior synechiae. Almost all imaged eyes (89%) had a visible open cleft, but many had inadequately controlled IOP. The presence of a cleft, residual trabecular meshwork or remnant of tissue, and open collector channels were not associated with IOP at the time of imaging, although our analysis did not control for other treatment variables that may have masked associations of IOP with anatomical features.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1016/j.jaapos.2025.104265 | DOI Listing |
Unlabelled: Abnormal development of the intricate trabecular meshwork (TM) or Schlemm's canal (SC) structures in the eye can result in reduced aqueous humor fluid drainage and elevated intraocular pressure. If left untreated, these processes can lead to retinal ganglion cell loss, damage to the optic nerve, and infant-onset vision loss, termed congenital glaucoma. To identify gene expression important for development of these specialized aqueous humor outflow pathway (AHOP) structures, single-cell RNA sequencing was performed on rat AHOP tissues during three major periods of growth.
View Article and Find Full Text PDFOphthalmol Glaucoma
September 2025
Department of Ophthalmology, Icahn School of Medicine at Mount Sinai, New York.
Genetic analyses have led to the identification of 12 genes primarily responsible for early-onset glaucoma and hundreds of genomic loci influencing adult-onset disease risk. Childhood glaucoma genes encode for proteins involved in ocular development and extracellular matrix, while genetic factors influencing adult-onset disease are involved in a number of biological pathways and processes. Genes responsible for glaucoma and genetic factors influencing disease risk can be used for genetic testing, allowing for informed genetic counseling for early-onset glaucoma cases and families and risk stratification using PRS for adult-onset disease.
View Article and Find Full Text PDFOphthalmol Sci
July 2025
Department of Ophthalmology, Harvey and Bernice Jones Eye Institute, University of Arkansas for Medical Sciences (UAMS) Medical Center, Little Rock, Arkansas.
Purpose: To evaluate the cumulative incidence of strabismus in childhood glaucoma and compare its risk to that in healthy controls.
Design: A retrospective clinical cohort study.
Participants: Childhood glaucoma patients aged ≤18 years from the TriNetX US Collaborative Network.
PLoS One
August 2025
Department of Regulatory Science, Graduate School, Kyung Hee University, Seoul, Republic of Korea.
Pediatric cataracts are a significant cause of childhood blindness, requiring long-term management. This study evaluated the economic burden of pediatric cataract surgery in South Korea and identified factors influencing the medical costs, particularly in patients with complications after cataract surgery. We used National Health Insurance Service claims data, covering the Korean population, including pediatric patients (aged ≤5 years) who underwent cataract surgery between 2004 and 2011.
View Article and Find Full Text PDFJ Proteins Proteom
May 2025
Wills Eye Hospital, Thomas Jefferson University, 840 Walnut Street, Philadelphia, PA 19107, USA.
Cytochrome P450 1B1 (CYP1B1) plays a critical role in the pathogenesis of primary congenital glaucoma (PCG), a severe eye disorder that can lead to pediatric blindness if untreated. Increasing evidence suggests that intrinsically disordered proteins and regions (IDPs/IDPRs), which lack a stable three-dimensional structure, are significant in disease pathology due to their flexible nature, impacting protein interactions and function. This study explores the intrinsic disorder within CYP1B1 and its implications in the molecular mechanisms underlying PCG.
View Article and Find Full Text PDF