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The ethics of palliative sedation has been debated intensely. Recently, it has been emphasised that many drugs with sedating effects are also effective in reducing specific symptoms like pain and seizures. For example, midazolam is commonly used to sedate terminally ill patients but it can also reduce seizures. Hence, when midazolam is administered to a patient suffering from seizures, it may also lower the patient's consciousness. Similarly, morphine is useful in the management of end-stage pain and dyspnoea, but can also reduce the patient's consciousness, especially when administered in large doses. Cases in which a drug thus alleviates a symptom as well as lowers patient consciousness are called double-effect sedation (DES). Many claim that the decrease in consciousness in DES is merely a side effect and not an intended consequence, even if its occurrence was foreseen in advance or it will be maintained for some time until the patient dies. Additionally, it is often contended that DES is therefore justifiable by the doctrine of double effect (DDE) even though the decrease in consciousness is bad. The purpose of this paper is to examine these claims. I argue that the claims, while sometimes correct, are very frequently false. It will be shown that physicians often intend to reduce consciousness in DES. In such cases, as I conclude, DDE may not serve to justify DES, and DES should be subject to the same rigorous moral evaluations as the use of sedating drugs that do not reduce specific symptoms.
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http://dx.doi.org/10.1136/jme-2025-110912 | DOI Listing |
J Vitreoretin Dis
September 2025
iMIND Study Group, Department of Ophthalmology, Duke University School of Medicine, Durham, NC, USA.
To assess retinal layer thickness and volume by optical coherence tomography (OCT) in patients with prior traumatic brain injury (TBI). Adults (≥18 years) with prior TBI were prospectively recruited. 512 × 128-mm macular cube scans were obtained using Zeiss Cirrus HD-5000 OCT.
View Article and Find Full Text PDFJ Am Geriatr Soc
September 2025
Frailty Research Center, Hinda and Arthur Marcus Institute for Aging Research, Hebrew SeniorLife, Boston, Massachusetts, USA.
Background: Prehabilitation may help older adults recover after surgery, yet adherence has been variable. We assessed the feasibility of a multi-component prehabilitation program.
Methods: This single-arm trial was conducted at an academic medical center to test the feasibility of an individualized prehabilitation program before major surgery.
Brain Topogr
September 2025
School of Biomedical Sciences, University of New South Wales (UNSW), Wallace Wurth Building, Kensington, NSW, 2052, Australia.
Different levels of reduced consciousness characterise human sleep stages at the behavioural level. On electroencephalography (EEG), the identification of sleep stages predominantly relies on localised oscillatory power within distinct frequency bands. Several theoretical frameworks converge on the central significance of long-range information sharing in maintaining consciousness, which experimentally manifests as high functional connectivity (FC) between distant brain regions.
View Article and Find Full Text PDFDrug Des Devel Ther
September 2025
Department of Anaesthesiology, Weifang People's Hospital, Weifang, People's Republic of China.
Purpose: To investigate the effects of low-dose alfentanil on the 50% effective dose (ED)/95% effective dose (ED) of remimazolam for successful loss of consciousness during general anesthesia in pediatric patients.
Patients And Methods: Fifty-two pediatric patients (aged 3-12, ASA I-II) scheduled for elective surgery were divided into two groups: Group A (n=24;alfentanil 5 μg kg + remimazolam 0.1 mg kg) and Group C (n=28;saline + remimazolam 0.
Neurosci Conscious
September 2025
School of Medicine, University of Toyama, 2630, Sugitani, Toyama 930-0152, Japan.
Integrated information theory (IIT) offers an axiomatic framework based on phenomenological properties, allowing the quantification and characterization of consciousness through a measure known as Φ. According to IIT, Φ reflects the level of consciousness and is expected to decrease with loss of consciousness, although empirical data supporting this claim remain limited. In this study, we analyzed two functional magnetic resonance imaging (fMRI) datasets acquired during anesthesia (propofol-induced) and natural sleep to determine whether Φ changes with the loss and recovery of consciousness.
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