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Traumatic brain injury (TBI) causes deficits in sensory systems, sensorimotor integration, and/or neuromuscular response, thus impairing essential postural response mechanisms such as compensatory postural adjustments. This, in turn, results in balance deficits and increases the risk of falls, affecting the activities of daily living and quality of life. Therefore, the goal of this study is to quantify the differences in neuromuscular responses based on electromyography (EMG) between people with TBI (pwTBI) and age-matched healthy controls (HCs). We investigated the differences between eight HCs and nine pwTBI in the following EMG characteristics: muscle activity (EMG) onset, EMG burst area, and median frequency, in response to anterior (forward) platform perturbations at four different amplitudes during standing. The results showed delayed muscle activation onset, larger EMG bursts, and decreased EMG median frequency in pwTBI compared to HCs, suggesting an altered neuromuscular response to platform perturbations in pwTBI.
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http://dx.doi.org/10.1109/TNSRE.2025.3592477 | DOI Listing |
J Neurol
September 2025
Department of Neurology, Xuanwu Hospital, National Center for Neurological Disorders, Capital Medical University, Beijing, China.
Background And Purpose: Efgartigimod has demonstrated efficacy in generalized myasthenia gravis (gMG) in both clinical trials and real-world studies. However, factors influencing early response have been less reported. This study aimed to evaluate the efficacy of efgartigimod in a multicenter gMG cohort and to identify the clinical factors associated with early therapeutic response.
View Article and Find Full Text PDFFront Physiol
August 2025
Facultad de Ciencias Biomédicas y de la Salud, Universidad Alfonso X el Sabio (UAX), Madrid, Spain.
Training structures such as every minute on minute (EMOM), as many repetitions as possible (AMRAP), and rounds for time (RFT) have gained popularity for improving sport performance and general health. However, limited research exists on how different relative loads affect neuromuscular and cardiorespiratory responses. This study aimed to compare acute effects on heart rate (HR), mean propulsive velocity (MPV), velocity loss, and pacing in participants performing AMRAP, EMOM, and RFT using the same absolute but varying relative loads.
View Article and Find Full Text PDFCurr Opin Neurol
October 2025
Neuromuscular Diseases Unit, Department of Neurology, IR SANT PAU, Hospital de la Santa Creu i Sant Pau, CIBERER, Barcelona, Spain.
Purpose Of Review: Autoimmune nodopathies (AN) are a recognized distinct group of immune-mediated peripheral neuropathies with unique immunopathological features and therapeutic implications. This review synthesizes recent advances in their pathogenesis, diagnosis, and management, which have refined their clinical classification and informed targeted treatment strategies.
Recent Findings: AN are characterized by autoantibodies targeting surface proteins in the nodal-paranodal area (anti-contactin-1, anti-contactin-associated protein 1, anti-neurofascin-155, anti-pan-neurofascin), predominantly of IgG4 subclass.
Neurologia (Engl Ed)
September 2025
Unidad de ELA-Neuromuscular, Servicio de Neurología, Hospital General Universitario Gregorio Marañón, Madrid, Spain; IiSGM, Instituto de Investigación Sanitaria Gregorio Marañón.
Objectives: To describe the main features and the clinical management of a cohort of patients with immune-mediated necrotizing myopathy (IMNM).
Methods: We conducted an observational, monocentric, retrospective study of IMNM patients diagnosed in the Neuromuscular Unit of a tertiary hospital in Madrid (Spain) between 2013 and 2021.
Results: Sixteen IMNM cases were diagnosed, with a median age of 71.
Percept Mot Skills
September 2025
Department of Physical Education and Health, Higher Institute of Physical Education, University of the Republic, Montevideo, Uruguay.
Tabata-based High-Intensity Functional Training (HIFT) elicits hybrid adaptations in both cardiorespiratory and neuromuscular systems. However, its high Rating of Perceived Exertion (RPE) may limit its feasibility. This study aimed to analyze the acute physiological and psychological responses to a modified low-volume Tabata-based HIFT incorporating short efforts, with a focus on potential differences between sexes.
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