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http://dx.doi.org/10.1021/acs.chemrev.5c00246 | DOI Listing |
Chem Rev
July 2025
Department of Cellular and Molecular Pharmacology and Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, California 94158, United States.
Front Pharmacol
December 2024
Department of Biotechnology, Indian Institute of Technology Hyderabad, Sangareddy, Telangana, India.
Introduction: Robust connections have been identified between the pathophysiology of mental disorders and the functioning of the circadian system. The overarching objective of this study was to investigate the potential for circadian rhythms to be leveraged for therapeutics in mental disorders.
Methods: We considered two approaches to chronotherapy-optimal timing of existing medications ("clocking the drugs") and redressing circadian abnormalities with small molecules ("drugging the clock").
Expert Opin Ther Targets
November 2024
Gottfried Schatz Research Center, Medical Physics and Biophysics, Medical University of Graz, Graz, Austria.
Introduction: Intensive and detailed investigations of the molecular function and cellular role of mammalian transient receptor potential canonical (TRPC) channels started back in the early 90 of the past century. Initial TRPC research was fueled by high hopes to resolve fundamental questions of cellular Ca signaling. To date, we have learned important lessons in TRPC channel biology and biophysics, while little progress has been made in terms of therapeutic concepts.
View Article and Find Full Text PDFCell Chem Biol
August 2024
Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390, USA. Electronic address:
Malaria remains a global health concern as drug resistance threatens treatment programs. We identified a piperidine carboxamide (SW042) with anti-malarial activity by phenotypic screening. Selection of SW042-resistant Plasmodium falciparum (Pf) parasites revealed point mutations in the Pf_proteasome β5 active-site (Pfβ5).
View Article and Find Full Text PDFExpert Opin Drug Discov
May 2024
Nanion Technologies GmbH, Munich, Germany.
Introduction: Automated patch clamp (APC) is now well established as a mature technology for ion channel drug discovery in academia, biotech and pharma companies, and in contract research organizations (CRO), for a variety of applications including channelopathy research, compound screening, target validation and cardiac safety testing.
Areas Covered: Ion channels are an important class of drugged and approved drug targets. The authors present a review of the current state of ion channel drug discovery along with new and exciting developments in ion channel research involving APC.