Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Aim: To explore the co-development and possible risk factors of frailty and functional ability among community-dwelling older adults.
Methods: This secondary analysis used data from a prospective three-wave cohort study with a sample of 780 older adults. Frailty was assessed using the Tilburg Frailty Indicator, and functional ability using the Lawton Instrumental Activities of Daily Living Scale. A conditional parallel-process latent growth curve model was implemented to test their dynamic relationship and explore the potential risk factors.
Results: Frailty and functional ability significantly deteriorated over 3 years. Older adults with severer frailty were more likely to experience poor initial functional ability as well as a faster loss of functional ability, and a rapid functional ability decline was more easily observed in participants suffering an accelerating increase in frailty deterioration. Furthermore, lack of a spouse and the presence of comorbidities were significantly related to severer initial frailty, while lower educational attainment was associated with poorer baseline functional ability. Advanced age impaired initial functional ability and accelerated its rate of deterioration over time.
Conclusions: Frailty and functional ability significantly deteriorated over a 3-year period, and the frailty trajectory significantly affected the evolution of functional ability. In addition, age, marital status, educational level, and multimorbidity were significant risk factors. These results underscore the importance of timely and tailored approaches addressing frailty and risk factors for maintaining functional ability and promoting healthy aging among community-dwelling older populations. Geriatr Gerontol Int 2025; ••: ••-••.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/ggi.70136 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Effect of inpatient rehabilitation on self-care and functional activities in acute ischemic stroke patients who underwent thrombectomy.
Neurol Res
September 2025
Zeenat Qureshi Stroke Institute and Department of Neurology, University of Missouri, Columbia, MO, USA.
Background: The benefits of rehabilitation in acute ischemic stroke patients following thrombectomy remain underexplored. We assessed which activities of daily living (ADLs) show the greatest improvement after goal-directed therapy in an inpatient rehabilitation setting.
Methods: We retrospectively analyzed pre- and post-rehabilitation functional assessments in 40 acute ischemic stroke patients treated with mechanical thrombectomy.
A genetically encoded nanobody sensor reveals conformational diversity in β-arrestins orchestrated by distinct seven transmembrane receptors.
Proc Natl Acad Sci U S A
September 2025
Department of Biological Sciences and Bioengineering, Indian Institute of Technology, Kanpur 208016, India.
Agonist-induced interaction of G protein-coupled receptors (GPCRs) with β-arrestins (βarrs) is a critical mechanism that regulates the spatiotemporal pattern of receptor localization and signaling. While the underlying mechanism governing GPCR-βarr interaction is primarily conserved and involves receptor activation and phosphorylation, there are several examples of receptor-specific fine-tuning of βarr-mediated functional outcomes. Considering the key contribution of conformational plasticity of βarrs in driving receptor-specific functional responses, it is important to develop novel sensors capable of reporting distinct βarr conformations in cellular context.
View Article and Find Full Text PDFCaregiver Burden and 30-Day Emergency Department Revisits.
JAMA Netw Open
September 2025
Centre de recherche intégrée pour un système apprenant en santé et services sociaux, Centre intégré de santé et de services sociaux de Chaudière-Appalaches, Lévis, Québec, Canada.
Importance: Caregivers of community-dwelling older adults play a protective role in emergency department (ED) care transitions. When the demands of caregiving result in caregiver burden, ED returns can ensue.
Objective: To develop models describing whether caregiver burden is associated with ED revisits and hospital admissions up to 30 days after discharge from an initial ED visit.
Parent/caregiver perspectives of meaningful improvement in functional domains for people with CDKL5 deficiency disorder: a mixed-methods study.
Qual Life Res
September 2025
The Kids Research Institute Australia, The University of Western Australia, P.O. Box 855, West Perth, WA, 6872, Australia.
Purpose: CDKL5 deficiency disorder (CDD) is a rare developmental and epileptic encephalopathy. Greater understanding of the smallest meaningful improvements for individuals with CDD in clinical trials and practice is needed for a person-centred approach to treatment efficacy. This study explored how parent/caregivers of people with CDD understood meaningful improvements and described change for priority functional domains including communication, gross motor, fine motor, feeding.
View Article and Find Full Text PDFFeasibility of a Gamified Mobile-Based Self-Management Intervention for Individuals With Nonspecific Chronic Lower Back Pain.
Nurs Res
September 2025
College of Nursing & Institute of Nursing Research, Korea University, Seoul, South Korea.
Background: Existing research fails to address the complex nature of nonspecific chronic lower back pain (cLBP ) despite its detrimental effect on economic, societal, and medical expenditures.
Objectives: We developed a nurse-led, mobile-delivered self-management intervention-Problem-Solving Pain to Enhance Living Well (PROPEL-M)-and evaluated its usability, feasibility, and initial efficacy for South Korean adults with nonspecific cLBP.
Methods: This study was composed of two phases: (a) lab and field usability testing for a gamified mobile device application; and (b) a pilot study employing a one-arm pre-test and post-test design among adults aged 18-60 years with nonspecific cLBP.