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The Abbreviated Profile of Hearing Aid Benefit (APHAB) has been one of the most frequently used patient-reported outcome measures (PROMs) since its inception 30 years ago. For the APHAB, single-valued 95% critical differences have been presented for the identification and interpretation of meaningful benefits in research and in the clinic. A narrative literature review of studies that used the global APHAB score as a hearing-aid outcome measure showed that the average benefit varied directly with the average unaided baseline score for each measure. Next, data from 584 older adults enrolled in our recently completed randomized controlled hearing-aid trial were examined. The same dependence of benefit scores on unaided baseline scores was observed in these data. Regression to the mean made relatively minor contributions to the observed dependence of APHAB scores on baseline unaided scores. These results indicate that the application of a single value for the 95% critical difference is not valid for the interpretation of APHAB scores. Rather, baseline-specific benefit criteria are needed. Based on these results, baseline-specific Minimal Detectable Differences (MDDs; or 95% critical differences) and Minimal Clinically Important Differences (MCIDs) using both distribution-based and anchor-based approaches were generated for the APHAB-global score.
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http://dx.doi.org/10.1177/23312165251359755 | DOI Listing |
Zhonghua Jie He He Hu Xi Za Zhi
September 2025
Pulmonary and Critical Care Medicine, The First Medical Center of Chinese PLA General Hospital, Beijing 100853, China.
To explore the feasibility and accuracy of predicting respiratory tract infections (RTIs) using physiological data obtained from consumer-grade smartwatches. The study used smartwatches and paired mobile applications to continuously collect physiological parameters while participants slept. A personalized baseline model was established using multi-day data, followed by the construction of RTIs risk prediction algorithm based on deviations from physiological parameter trends.
View Article and Find Full Text PDFInt J Biol Macromol
September 2025
Department of Computational Biology, Indraprastha Institute of Information Technology Delhi (IIIT-Delhi), Okhla Phase III, New Delhi, 110020, India; Infosys Centre for Artificial Intelligence, Indraprastha Institute of Information Technology Delhi (IIIT-Delhi), Okhla Phase III, New Delhi, 110020, In
Understanding the structural and functional diversity of toxin proteins is critical for elucidating macromolecular behavior, mechanistic variability, and structure-driven bioactivity. Traditional approaches have primarily focused on binary toxicity prediction, offering limited resolution into distinct modes of action of toxins. Here, we present MultiTox, an ensemble stacking framework for the classification of toxin proteins based on their molecular mode of action: neurotoxins, cytotoxins, hemotoxins, and enterotoxins.
View Article and Find Full Text PDFJ Med Internet Res
September 2025
Division of Informatics, Imaging and Data Sciences, University of Manchester, Oxford Rd, Manchester, M13 9PL, United Kingdom, 44 7534135812.
Background: Telemedicine has revolutionized the management of type 2 diabetes mellitus (T2DM) in primary care by improving access to health care services and enhancing health outcomes. Despite these advancements, it remains unclear whether telemedicine has reduced access inequalities among different demographic and socioeconomic groups.
Objective: This study aimed to investigate the most important demographic and socioeconomic factors associated with telemedicine use among individuals with T2DM in primary care.
Eur J Cancer
August 2025
Emory University, Atlanta, USA; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA; Atlanta Veterans Administration Medical Center, Atlanta, USA. Electronic address:
Background: Early detection of hematological malignancies improves long-term survival but remains a critical challenge due to heterogeneity in clinical presentation. Chronic inflammation is a key driver in hematologic cancers and is known to induce compensatory microvascular changes. High-resolution, non-invasive retinal imaging can allow the quantification of microvascular changes for the early detection of hematological malignancies.
View Article and Find Full Text PDFAm J Emerg Med
September 2025
Department of Surgical Education, Orlando Regional Medical Center, Orlando, FL, USA; Department of Surgery, Division of Trauma and Surgical Critical Care, Orlando Regional Medical Center, Orlando, FL, USA. Electronic address:
Background: There is conflicting literature regarding mortality outcomes associated with REBOA usage in patients with severe thoracic or abdominal trauma. Our study aims to assess the benefits and negative implications of REBOA use in adult trauma patients in hemorrhagic shock with severe thoracic or abdominal injuries.
Methods: This retrospective cohort analysis utilized the American College of Surgeons Trauma Quality Improvement Program Participant Use File (ACS-TQIP-PUF) database from 2017 to 2023 to evaluate adult patients with severe isolated thoracic or abdominal trauma undergoing REBOA placement.