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Mystical experiences (MEs) are often profound and transformative encounters with a transcendent reality. Reported across many cultures and religions, these experiences are commonly characterized by a sense of unity, transcendence of time and space, positive mood, ineffability, and a noetic quality. Theoretical models have emphasized psychological, neurological, and sociocultural explanations to account for their positive effects on individuals, and psychometric tools have been developed to offer standardized methods to assess experience intensity and impact. MEs indicate significant potential in clinical psychology and have demonstrated psychotherapeutic benefit in the treatment of various conditions. We propose a novel conceptual framework to guide future use of MEs in therapeutic contexts, as interest in the mystical realm exponentially grows. The framework centers around the ME itself highlighting a requisite non-ordinary state of consciousness to foster intensely felt experiences occasioning profound psychological impact. The framework posits that MEs require three pre-state factors: invitation, context, and individual aptitude. After experiencing an ME, a necessary mediating factor in experiencing beneficial change is the process of integration.
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http://dx.doi.org/10.1080/00207144.2025.2526351 | DOI Listing |
Background: Psychedelics can acutely induce mystical experiences and elevated positive mood, which may contribute to the potential benefits of psychedelic therapy. However, there remains limited understanding of the occurrence and importance of specific positive emotional experiences within psychedelic therapy. Therefore, we examined the effects of psychedelics on positive emotional experiences and their association with improvements in mental health.
View Article and Find Full Text PDFFront Hum Neurosci
August 2025
Faculty of Psychotherapy Science, Sigmund Freud Private University, Vienna, Austria.
Oceanic states of consciousness-characterized by ego dissolution, unity, and timelessness-have long occupied a liminal space between psychopathology and transcendence. This paper explores these states through the interdisciplinary lens of existential neuroscience, integrating insights from psychoanalysis, existentialism, affective neuroscience, and psychedelic research. Starting with the psychoanalytic tension between Freud's view of the oceanic feeling as a regressive illusion and Jung's framing of it as a transformative encounter with the unconscious, this paper examines how creative and mystical experiences often arise from this dissolution of self-boundaries.
View Article and Find Full Text PDFGen Hosp Psychiatry
August 2025
Department of Psychosocial Cancer Care, St. Vincent's Hospital Melbourne, Fitzroy, VIC, Australia; Palliative Medicine Unit, St. Vincent's Hospital Melbourne, Fitzroy, VIC, Australia.
Importance: Psilocybin-assisted psychotherapy may offer a novel approach to treating depression, anxiety, and existential distress in individuals with life threatening illnesses, where current treatments show limited efficacy.
Objective: To evaluate the efficacy and safety of psilocybin-assisted psychotherapy versus active placebo and psychotherapy in adults with life-threatening illnesses.
Design: Double-blind, randomized controlled phase 2b trial (RCT) with an open-label extension and 6-month follow-up (January 2020 - October 2023).
Front Psychol
July 2025
Coma Science Group, GIGA-Consciousness, University of Liège, Liège, Belgium.
Near-death experiences (NDEs), a syndrome of experiences with mystical-type content classically arising in the context of life-threatening situations, are under-researched in terms of their relevance for acute medical care. We here discuss several reasons to raise the importance of conducting more comprehensive NDE research in emergency and critical care contexts, including but not limited to near-death experiencers' awareness of surroundings and the need for patient support given NDEs' profound psychological impacts, and we suggest incorporating the identification of NDEs into management plans. Exploring NDE incidence and their subsequent impact in acute settings may unveil a pathway toward favorable outcomes within clinical practice.
View Article and Find Full Text PDFJ Perinat Educ
July 2025
SisterWeb San Francisco Community Doula Network, San Francisco, CA, USA.
This qualitative study examines the impact of working for SisterWeb San Francisco Community Doula Network, a community-based doula organization, on Black and Pacific Islander doulas who provide culturally congruent support to individuals before, during, and after childbirth. We interviewed eight doulas at three timepoints (2020, 2021, and 2022). Participants described how their confidence as doulas grew while working at SisterWeb, partially due to gaining more experience as birth workers within a supportive learning environment.
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