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Background And Objectives: To investigate the current status of clinical pathway implementation for food for special medical purpose (FSMP) in China and provide a scientific basis for constructing a standardized pathway.
Methods And Study Design: An E-questionnaire was distributed to 27 clinical nutrition quality control centers in tertiary medical institutions in China from September to October 2023 via random stratified sampling.
Results: Ninety-eight valid questionnaires were ultimately recovered. The number of FSMPs used ranged from 1 to 33. The rates of active nutritional risk screening, nutritional status assessment and diagnosis before FSMP therapy were 93.87, 93.88, and 97.96%, respectively. In addition to nutritional physicians, dietitians, and clinicians, nurses participated in prescribing FSMP in 12.24% of the hospitals. Before a prescription was issued, 65 (66.33%) hospitals had an audit process conducted by superior clinicians or dietitians. The frequency of routine ward rounds for more than half of the hospitalized inpatients was once a day. Post-discharge follow-up was implemented in 57 (58.16%) hospitals. The preparation of FSMP in 77 (87.50%) hospitals was included in the supervision of nosocomial infection. The frequency of infection supervision in half of the hospitals was once a month. Sixty-four (65.31%) hospitals had established monitoring and treatment plans for FSMP adverse reactions. Eighteen (18.37%) hospitals had set up FSMP counters for patients. Outpatients from 79 (80.61%) hospitals received FSMP in the department of clinical nutrition. Forty-five (45.92%) hospitals had charge codes. More than 20 different types of charges were collected.
Conclusion: An FSMP clinical pathway prototype (Nutritional Screening-Assessment-Diagnosis-Treatment) has been implemented in China's tertiary medical institutions. However, many irregularities exist. A standardized clinical pathway with universality and enforceability needs to be developed and promoted. There is an urgent need for China to strengthen its regulation policies and for other countries to share their experiences in the clinical application of FSMP.
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http://dx.doi.org/10.3389/fmed.2025.1538105 | DOI Listing |
Biomaterials
September 2025
Key Laboratory of Biopharmaceutical Preparation and Delivery, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100190, PR China; University of Chinese Academy of Sciences, Beijing, 100049, PR China. Electronic address:
The stimulator of interferon genes (STING) pathway represents a promising target in cancer immunotherapy. However, the clinical translation of cyclic dinucleotide (CDN)-based STING agonists remains hindered by insufficient formation of functional CDN-STING complexes. This critical bottleneck arises from two interdependent barriers: inefficient cytosolic CDN delivery and tumor-specific STING silencing via DNA methyltransferase-mediated promoter hypermethylation.
View Article and Find Full Text PDFNeurol Neuroimmunol Neuroinflamm
November 2025
Departments of Neurology and Ophthalmology, NYU Grossman School of Medicine, NY; and.
Background And Objectives: While reductions in optical coherence tomography (OCT) pRNFL and ganglion cell-inner plexiform layer thicknesses have been shown to be associated with brain atrophy in adult-onset MS (AOMS) cohorts, the relationship between OCT and brain MRI measures is less established in pediatric-onset MS (POMS). Our aim was to examine the associations of OCT measures with volumetric MRI in a cohort of patients with POMS to determine whether OCT measures reflect CNS neurodegeneration in this patient population, as is seen in AOMS cohorts.
Methods: This was a cross-sectional study with retrospective ascertainment of patients with POMS evaluated at a single center with expertise in POMS and neuro-ophthalmology.
J Med Chem
September 2025
School of Pharmacy, Hangzhou Normal University, Hangzhou 311121, PR China.
The prevalence of AGA is continuously rising, with an earlier age of onset. Currently, only minoxidil and finasteride have received FDA approval for the treatment of AGA, inadequately addressing the pressing clinical needs. Recently, the involvement of the Wnt/β-catenin signaling pathway in AGA has attracted increased research interest.
View Article and Find Full Text PDFACS Nano
September 2025
Department of Emergency and Critical Care Medicine, The Fourth Affiliated Hospital of Soochow University, Suzhou 215124, China.
Acute lung injury (ALI) is characterized by the excessive accumulation of reactive oxygen species (ROS), which triggers a severe inflammatory cascade and the destruction of the alveolar-capillary barrier, leading to respiratory failure and life-threatening outcomes. Considering the limitations and adverse effects associated with current therapeutic interventions, developing effective and safe strategies that target the complex pathophysiological mechanisms of ALI is crucial for improving patient outcomes. Herein, we developed an inhalable, multifunctional nanotherapeutic (MSCNVs@CAT) by encapsulating catalase (CAT) in mesenchymal-stem-cell-derived nanovesicles (MSCNVs).
View Article and Find Full Text PDFBrain
September 2025
Aix Marseille Univ, INSERM, INS, Inst Neurosci Syst, 13005 Marseille, France.
The lateral prefrontal cortex (LPFC) serves as a critical hub for higher-order cognitive and executive functions in the human brain, coordinating brain networks whose disruption has been implicated in many neurological and psychiatric disorders. While transcranial brain stimulation treatments often target the LPFC, our current understanding of connectivity profiles guiding these interventions based on electrophysiology remains limited. Here, we present a high-resolution probabilistic map of bidirectional effective connectivity between the LPFC and widespread cortical and subcortical regions.
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