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http://dx.doi.org/10.21037/tcr-2025-505 | DOI Listing |
Eur J Gastroenterol Hepatol
August 2025
Department of Gastroenterology and Hepatology, Noordwest Ziekenhuisgroep, Alkmaar.
Currently, symptomatic gastrointestinal (GI) angiodysplasia is treated with argon plasma coagulation (APC) via endoscopic procedures, supplemented with octreotide or thalidomide treatment. However, suboptimal response and side effects are often seen. Bevacizumab, an angiogenesis inhibitor, may provide an alternative systemic therapy for patients with refractory GI angiodysplasia.
View Article and Find Full Text PDFPol Merkur Lekarski
September 2025
LLC "ECOFARM", KYIV, UKRAINE.
Objective: Aim: To consider the specific activity of drops and suppositories of PROTEFLAZID® at the stage of preclinical study, to assess the effectiveness and safety of use in clinical practice in papillomavirus-associated diseases of the female reproductive system..
Patients And Methods: Materials and Methods: Analysis of scientific publications on the treatment of palilomavirus infection with PROTEFLAZID® in women over the past decade.
Pol Merkur Lekarski
September 2025
DEPARTMENT OF GENERAL, ONCOLOGIC AND METABOLIC SURGERY, INSTITUTE OF HEMATOLOGY AND TRANSFUSION MEDICINE, WARSAW, POLAND.
Objective: Aim: The study aims to evaluate the impact of the ONSTEP technique on the intensity of the systemic inflammatory response syndrome (SIRS) and the outcomes of inguinal hernia treatment compared to the Lichtenstein technique. .
Patients And Methods: Materials and Methods: In 41 men randomized into 2 study groups, unilateral inguinal hernia repair was performed using the ONSTEP technique in group O and the Lichtenstein technique in group L.
PLoS One
September 2025
Department of Cardiac Surgery, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Background: Cardiac ischemia reperfusion (I/R) injury is a serious consequence of reperfusion therapy for myocardial infarction (MI). Peptidylarginine deiminase 4 (PAD4) is a calcium-dependent enzyme that catalyzes the citrullination of proteins. In previous studies, PAD4 inhibition protected distinct organs from I/R injury by preventing the formation of neutrophil extracellular traps (NETs) and attenuating inflammatory responses.
View Article and Find Full Text PDFCornea
September 2025
Cornea Department, Ophthalmic Consultants of Long Island, Rockville Center, NY.
Purpose: This review and case report address ligneous conjunctivitis (LC), a rare ocular condition caused by plasminogen deficiency type 1 (PLGD-1), which manifests as wood-like fibrin-rich membranes on the palpebral conjunctiva. The goal is to provide ophthalmologists-often the first physicians to encounter the condition-with a robust understanding of its systemic manifestations and to highlight current therapeutic strategies, with particular emphasis on the administration of intravenous plasminogen concentrate.
Methods: We present a clinical LC case alongside a narrative review of published cases, etiology, and treatment approaches.