Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Objectives: This study aimed to assess the contribution of demographics, medical history, and psychological health to pupillary light reflex (PLR) indices in Service members with and without a history of mild traumatic brain injury (mTBI).
Methods: PLR data from NeurOptics NPi-300 were analyzed on 216 participants who were categorized as non-injured controls (NIC), mTBI with no loss of consciousness (mTBI), or mTBI with LOC (mTBI). Multiple independent regression models were conducted for each PLR index to assess the contribution of these factors to the variability of PLR indices by group.
Results: There were no significant group differences on the PLR indices. Age was a significant factor across groups, but more robust for those with mTBI. Sleep duration, injury characteristics, and psychological health effects on PLR indices were primarily observed in the mTBI group. Posttraumatic stress and sex were not significant predictors in any of the models.
Conclusions: When using PLR for screening of mTBI, an individual's age, history of prior mTBI, total lifetime TBI-related alterations in consciousness, sleep, and anxiety and depression symptoms should be considered when interpreting PLR metrics.
Significance: Controlling for these factors is essential for validating the use of PLR for screening of mTBI.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12274732 | PMC |
| http://dx.doi.org/10.1016/j.cnp.2025.07.002 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Complete Blood Count (CBC) Parameters as a Cost-Effective Tool for Early Diagnosis of Pediatric Sepsis: A Retrospective Cross-Sectional Study.
Cureus
August 2025
Department of Paediatrics, All India Institute of Medical Sciences, Raebareli, Raebareli, IND.
Introduction: Early recognition of pediatric sepsis is crucial for timely intervention, prevention of mortality, and improving long-term outcomes in children. However, the lack of advanced diagnostics in resource-limited settings poses a significant challenge to early diagnosis and intervention. Complete blood count (CBC) parameters are routinely performed, cost-effective, and readily available, yet their diagnostic utility in pediatric sepsis remains underutilized.
View Article and Find Full Text PDFComparison of Diagnostic Accuracies of Radiomics and Non-radiomics Model for Preoperative Prediction of Macrotrabecular-Massive Hepatocellular Carcinoma: A Systematic Review and Meta-analysis.
Acad Radiol
September 2025
Department of Radiology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China. Electronic address:
Rationale And Objectives: The diagnostic value of traditional imaging methods and radiomics in predicting macrotrabecular-massive hepatocellular carcinoma (MTM HCC) is yet to be ascertained. Therefore, this meta-analysis aims to compare the diagnostic performance of radiomics and conventional imaging techniques for MTM HCC.
Materials And Methods: Comprehensive publications were searched in PubMed, Embase, Web of Science, and Cochrane Library up to 28 February 2025.
Background: Based on the widespread use of the systemic immune-inflammation index (SII), neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and lymphocyte-monocyte ratio (LMR), markers, we aimed to calculate and compare the reference intervals (RIs) of these indices in adults, using both nonparametric method according to the Clinical and Laboratory Standards Institute's (CLSI) EP28-A3C:2010 guideline and refineR algorithm using a large dataset.
Methods: We analyzed data from 293,585 adults (18 - 65 years) retrospectively obtained from complete blood count results (using laboratory information system). The study involved a two-stage outlier exclusion process.
Stable cytokine network during hypoxia and exercise in patients with Fontan circulation.
Int J Cardiol
September 2025
Department of Molecular and Cellular Sports Medicine, German Sport University Cologne, Am Sportpark Müngersdorf 6, 50933 Cologne, Germany. Electronic address:
Background: Patients with Fontan circulation are often advised to avoid hypoxic exposure due to presumed cardiopulmonary vulnerability. Low-grade inflammation has also been reported in this population and may be influenced by hypoxia and/or exercise. Based on the potential interaction between hypoxia and submaximal exercise in modulating inflammatory signaling, we hypothesized that this combination could exacerbate subclinical inflammation.
View Article and Find Full Text PDFIntroduction Chronic Obstructive Pulmonary Disease (COPD) is increasingly recognized not only as a pulmonary condition but as a systemic disorder with significant cardiovascular implications. Acute exacerbations of COPD (AECOPD) further elevate this risk, potentially through a heightened prothrombotic state. This study aimed to evaluate and compare the levels of select prothrombotic biomarkers - fibrinogen, C-reactive protein (CRP), D-dimer, von Willebrand Factor (vWF), homocysteine, lactate dehydrogenase (LDH), and platelet-to-lymphocyte ratio (PLR) - in patients with stable COPD and AECOPD, and to assess their diagnostic and prognostic significance.
View Article and Find Full Text PDF