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The goals of the complementary feeding period starting from 4 to 6 months of age are to fulfill the infant's nutritional need for nutrients and expose the infant to foods of varying flavors and textures to encourage acceptance of a diverse and nutritionally complete diet. Healthy complementary feeding consists of the timely introduction of a high diversity of whole, nutrient dense, and home-cooked foods or alternatively commercially frozen meals based on whole ingredients without added sugar or salt. These meals consist of predominantly plant-based foods, such as fruits, vegetables, legumes, grains, as well as fermented foods such as yoghurt. Healthy complementary foods are rich in fiber, iron, zinc, omega-3, and low in sugar, salt, and ultra-processed ingredients. In addition, these foods are hygienically safe, properly prepared, and include the early introduction of family-adjusted and country-specific food allergens. In this way regular complementary foods contribute to taste development, age-appropriate oral motor skills, and the prevention of allergic disease, not only by early introduction of food allergens but also by its impact on a healthy and diverse gut microbial development, a healthy immune maturation, and mucosal tolerance. Thus, individualized timing and selection of appropriate foods are essential while avoiding overreliance on infant formula and commercial baby foods as well as non-recommended feeding styles. This paper provides a rationale and guidance for health care professionals on healthy choices for complementary foods beyond early introduction of common allergens in children up to 24 months of age in developed countries.
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http://dx.doi.org/10.1111/pai.70150 | DOI Listing |
Front Neurol
August 2025
Department of Neurology, Zhengzhou University People's Hospital, Henan Provincial People's Hospital, Zhengzhou, China.
Background: Myasthenia gravis (MG), an autoimmune disorder characterized by B cell-driven autoantibody production, exhibits heterogeneous B cell subsets dysregulation and incompletely defined signaling mechanisms.
Methods: A cohort of 20 naïve MG patients positive for anti-acetylcholine receptor (AChR) antibodies and 15 healthy controls was analyzed. Peripheral blood mononuclear cells underwent proteomic profiling, flow cytometry (age-associated B cells (ABCs), plasma cells, T follicular helper cells, and regulatory B cells), and western blot validation of nuclear factor kappa-B (NF-κB)/cellular reticuloendotheliosis oncogene homolog (c-Rel) expression.
Commercially processed complementary foods (CPCFs) are consumed in Kenya, but little is known about caregiver perceptions and reasons for their consumption. We explored caregiver perceptions, motivations and reasons for purchasing CPCFs. This cross-sectional mixed-methods study was conducted in Nairobi among caregivers of children aged 6-23 months.
View Article and Find Full Text PDFAging Clin Exp Res
September 2025
Department of Cardiovascular Medicine and Hypertension, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan.
Background: Intrinsic capacity (IC) and frailty are distinct but complementary frameworks for understanding the heterogeneity of aging. Although both have been linked to self-rated health, little is known about how their combined status relates to older adults’ health perceptions. This cross-sectional study investigated how combinations of IC and frailty status were associated with self-rated health among community-dwelling older adults.
View Article and Find Full Text PDFEur Arch Psychiatry Clin Neurosci
September 2025
Department of Psychiatry and Psychotherapy, University of Lübeck, Ratzeburger Allee 160, 23538, Lübeck, Germany.
Background: Patients with schizophrenia spectrum disorder (SSD) suffer from impaired cognitive functions. Previous studies in healthy individuals have shown that a single bout of physical exercise benefits cognitive functions. Such enhancements in cognitive function would be highly beneficial, particularly for patients with SSD, as cognitive abilities play a vital role in both mental and physical health.
View Article and Find Full Text PDFJ Immunoassay Immunochem
September 2025
Área Inmunología, Departamento de Biociencias (DEPBIO), Facultad de Química, Universidad de la República, Montevideo, Uruguay.
Immunoassays are complementary diagnostic tools in human cystic echinococcosis (CE) despite sensitivity/specificity limitations, and synthetic peptides have been suggested to potentially overcome disadvantages reported for traditional antigens. Herein, a systematic study comparing the immunodiagnostic performance of AgB1 versus synthetic peptides derived from its sequence was carried out. Thus, a eukaryotic-expressed recombinant AgB1 was assessed, together with a reported synthetic peptide (p176, N-terminal portion of AgB1) and two new peptides within p176 (namely pB1a and pB1b) corresponding to predicted linear B-cell epitopes.
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