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The angular gyrus (AG) is widely implicated in language, memory, multisensory perception, and has been found to be a hub of connectivity. However, different strands of research on AG functions and structures have seldom been integrated. Recent event segmentation research, including Wu et al. (2025), shows that the AG robustly encodes event boundaries during spoken narratives, with stronger and more reliable involvement than the posterior cingulate cortex (PCC). This commentary situates such findings within broader insights from connectomic fingerprints and cortical topography - using the contrast between AG and PCC as an example - to suggest that different regions' topographic juxtaposition and connectivity pattern may underlie their differential roles in representing event structure across modalities. Integrating perspectives from research on event segmentation and the brain connectome offers new avenues for understanding how the brain encodes continuous streams of information from vision, hearing, and action to form a coherent experience.
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http://dx.doi.org/10.1016/j.cortex.2025.06.017 | DOI Listing |
J Neural Eng
September 2025
Laboratoire de Psychologie et NeuroCognition, Bâtiment Michel Dubois, 1251 Av. Centrale, 38041 Grenoble Cedex 09, Grenoble, Auvergne-Rhône-Alpes, 38040, FRANCE.
Objective: Transcranial magnetic stimulation (TMS) combined with electroencephalography (EEG) has become a valuable tool in clinical and cognitive neuroscience. However, TMS-EEG signals often suffer from severe artifacts, particularly in lateral cortical regions where TMS-evoked muscle arti-facts are pronounced, making real-time recovery of TMS-evoked potentials (TEPs) challenging. We developed and validated a real-time, two-step independent component analysis (ICA)-based artifact cleaning method for TMS-EEG signals, facilitating the rapid extraction of clean neural signals for closed-loop neurostimulation applications.
View Article and Find Full Text PDFJ Funct Biomater
July 2025
Scienze e Tecnologie Chirurgiche, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, Italy.
Atomic force microscopy (AFM)-based nanoindentation enables investigation of the mechanical response of biological materials at a subcellular scale. However, quantitative estimates of mechanical parameters such as the elastic modulus (E) remain unreliable because the influence of sample roughness on E measurements at the nanoscale is still poorly understood. This study re-examines the interpretation of roughness from a more rigorous perspective and validates an experimental methodology to extract roughness at each nanoindentation site-i.
View Article and Find Full Text PDFFood Chem X
July 2025
College of Food Science and Engineering, Yangzhou University, Yangzhou 225127, China.
This study investigated the impact of 3-methylbutanal (0, 60, 120, 180, 240, and 300 μg/kg) on aroma and neural responses in fermented sausages. Among 33 volatiles identified, 3-methylbutanal exhibited the highest odor activity value of 868, indicating its dominant contribution. Sensory analysis showed that samples with 180 μg/kg received the highest ratings for savory (7.
View Article and Find Full Text PDFSmall
August 2025
Department of Chemistry, Northwestern University, Evanston, IL, 60208, United States.
Nanotopography exhibits strong effects on cellular properties such as cytoskeletal organization and endocytosis. Responses to topographical cues can propagate into cell-scale characteristics like cortical stiffness as well as systemic effects like inflammation and implant rejection; however, the biological pathways governing these effects remain comparatively unknown. Here we show how the RhoA/ROCK pathway can regulate responses to nanotopographical features vis-à-vis cellular tension.
View Article and Find Full Text PDFImaging Neurosci (Camb)
March 2025
Brain and Mind Laboratory, Department of Neuroscience and Biomedical Engineering, Aalto University School of Science, Espoo, Finland.
Emotions modulate behavioral priorities based on exteroceptive and interoceptive inputs, and the related central and peripheral changes may be experienced subjectively. Yet, it remains unresolved whether the perceptual and subjectively felt components of the emotion processes rely on shared brain mechanisms. We applied functional magnetic resonance imaging, a rich set of emotional movies, and high-dimensional, continuous ratings of perceived and felt emotions in the movies to investigate their cerebral organization.
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