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Background: Subthreshold depression and anxiety are common, affecting up to 24 % of people over their lifetime and are often associated with long-term conditions. Community pharmacists, who often have an established relationship with people who have long-term conditions, are well placed to identify and address subthreshold depression and anxiety and reduce the risk of progression to clinical mental health disorders.
Methods: Semi-structured individual qualitative interviews were conducted with community pharmacists to explore their perspectives on a pharmacy service for long-term condition patients with subthreshold depression and anxiety. Interviews were audio recorded, transcribed in intelligent verbatim and analysed using a General Inductive Approach.
Results: Eleven purposively selected community pharmacists from diverse backgrounds were interviewed. Four main themes were identified, each with several subthemes. These related to existing support mechanisms for delivering long-term condition and mental health services in community pharmacies, pharmacists' perceptions and attitudes toward service delivery, barriers and facilitators to service implementation, and the design and implementation of a service.
Conclusions: This is the first study to explore community pharmacists' perspectives on a pharmacy intervention for long-term condition patients with subthreshold depression and anxiety. Overall, community pharmacists expressed positive attitudes toward delivering an intervention for people with long-term conditions and subthreshold depression and anxiety. Future work would involve taking a co-design approach to developing and evaluating such an intervention.
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http://dx.doi.org/10.1016/j.rcsop.2025.100629 | DOI Listing |
Int J Risk Saf Med
September 2025
Patient, Activist, and Independent Scholar, Newington, CT, USA.
This patient commentary addresses the absence of rigorous placebo- or sham-controlled trials for electroconvulsive therapy (ECT) and discusses whether its therapeutic effects are partly attributable to non-seizure components like anesthesia and subthreshold electrical stimulation. It proposes noninferiority trials comparing ECT and non-ictal treatments such as subconvulsive electrotherapies and psychotherapeutic anesthesia to investigate these components and evaluate potential alternatives with lesser adverse effects.
View Article and Find Full Text PDFBipolar Disord
September 2025
Department of Affective Disorder, The Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou, People's Republic of China.
Objective: Accumulative research indicates key roles of the peripheral inflammation system and hippocampal function in major mood disorders. The complement system modulates inflammatory function and is abnormal in mood disorders, but its precise neural pathway remains unclear. This study investigates the interrelations among complement component 3 (C3) levels, hippocampal function, and mood symptoms among offspring of bipolar disorder (BD) parents who carry familial risk of mood disorders.
View Article and Find Full Text PDFJ Affect Disord
August 2025
Department of Psychology, The Chinese University of Hong Kong, Hong Kong.
Objective: Understanding the clinical continuum of depression (encompassing Major Depressive Disorder (MDD) and Subthreshold Depression (SD)) is fundamental to developing detection and prevention, especially among adolescents where onset is common. Using an epidemiologic adolescent sample, this study examined the prevalence of MDD and SD, and compared psychosocial outcomes with healthy controls (HCs).
Method: A total of 2295 adolescents aged 12-17 were randomly selected from schools across Hong Kong.
Sci Rep
August 2025
Faculty of Human Sciences, School of Human Sciences, Waseda University, Mikeshima 2-chome 579-15, Tokorozawa, 359-1164, Saitama, Japan.
Depression is often linked to reduced facial expressivity and to biases in recognizing others' emotions. Whether subthreshold depression (StD)-a putative prodromal stage-shows comparable alterations remains unclear. We recorded 10‑second self‑introduction videos of Japanese undergraduates (ratees; n = 64) and obtained subjective impression ratings from a separate group (raters; n = 63).
View Article and Find Full Text PDFJ Psychopathol Clin Sci
August 2025
Department of Psychology, Stony Brook University.
Offspring of depressed parents at increased risk for developing depression. They also differ from offspring of nondepressed parents on numerous risk factors, including personality, cognitive biases, neural processing of emotional stimuli, subthreshold depression and anxiety and irritability symptoms, and interpersonal functioning (Goodman, 2020; Gotlib et al., 2023).
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