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Article Abstract
Introduction: Total-body positron emission tomography/computed tomography (PET/CT) using uEXPLORER scanners demonstrates superior imaging capabilities for assessing programmed death ligand 1 (PD-L1) expression heterogeneity between primary tumors (PTs) and metastatic tumors (MTs) in advanced nonsmall cell lung cancer (NSCLC).
Methods: This retrospective study of 99 treatment-naïve NSCLC patients revealed that metabolic parameters (SUVmax, SUR-L, and SUR-BP) derived from biopsy-correlated PET/CT sites significantly predicted high PD-L1 expression (TC ≥ 50% or IC ≥ 10% by IHC).
Results: SUR-L exhibited the highest diagnostic accuracy (AUC = 0.758, < 0.001). Among 30 immunotherapytreated patients, PD-L1 positivity and SUR-BP ≥ 7.30 were associated with prolonged disease-free survival (DFS) ( = 0.012 and = 0.035, respectively).
Discussion: Our findings establish SUR-BP as a novel non-invasive biomarker for immunotherapy prognosis in NSCLC, addressing spatial heterogeneity challenges in PD-L1 assessment.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12263409 | PMC |
| http://dx.doi.org/10.3389/fonc.2025.1578419 | DOI Listing |
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