Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
The increasing dangers of aging dyslipidemia, such as cardiovascular disease, which is one of the major causes of mortality globally, must be prevented and managed due to the detrimental consequences of age-associated dyslipidemia, particularly its dangerous effects on the cardiovascular system. Numerous studies have shown that various forms of physical activity, including strength training and moderate aerobic workouts, have a good impact on middle-aged, adult, and elderly people's lipid profiles, inflammatory responses, and cardiovascular risk. Besides exercise, natural substances found in fruits and plants, including polyphenols which have anti-inflammatory and antioxidant qualities, can also enhance health and slow down the effects of aging on changes in lipid profiles and cardiovascular irregularities. The impact of aging-related liver disease and dyslipidemia on cardiovascular abnormalities in the older population have been the subject of several research over the past 40 years. The precise mechanism of aging on the particular molecular mediators implicated in dyslipidemia in older adults has seldom been studied, despite the fact that several elements of the detrimental effects of aging on liver structure and function have been previously documented. Thus, in this study, we looked at how natural products and exercise affect hepatic transcriptional variables related to lipid metabolism.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12263415 | PMC |
| http://dx.doi.org/10.3389/fnut.2025.1531327 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Deletion of ABIN1-LIR motifs impairs hepatic lipid homeostasis and mitophagy via AMPK-TFEB axis in mice.
Am J Physiol Cell Physiol
September 2025
Institute of Pharmacology and Toxicology, Goethe University Frankfurt, Frankfurt, Germany.
The A20 binding inhibitor of nuclear factor-kappa B (NF-κB)-1 (ABIN-1) serves as a ubiquitin sensor and autophagy receptor, crucial for modulating inflammation and cell death. Our previous in vitro investigation identified the LC3-interacting region (LIR) motifs 1 and 2 of ABIN-1 as key mitophagy regulators. This study aimed to explore the in vivo biological significance of ABIN1-LIR domains using a novel CRISPR-engineered ABIN1-ΔLIR1/2 mouse model, which lacks both LIR motifs.
View Article and Find Full Text PDFCase Report: Pathogenic variants and nonsense-mediated mRNA decay result in an early-onset neutral lipid storage disease with myopathy.
Front Genet
August 2025
Laboratory of Cellular Biochemistry and Molecular Biology, CRIBENS, Catholic University of the Sacred Heart, Milan, Italy.
Neutral Lipid Storage Disease with Myopathy (NLSDM) is a rare lipid metabolism disorder caused by impaired Adipose Triglyceride Lipase (ATGL) activity, leading to neutral lipid accumulation in various tissues. It typically manifests with progressive skeletal myopathy, with an onset of around 35 years. In addition, some patients develop cardiomyopathy and liver dysfunction.
View Article and Find Full Text PDFTotal ginsenosides enhance γ-globin expression and fetal hemoglobin production in β-thalassemia models.
Front Pharmacol
August 2025
Department of Medical Genetics, NHC Key Laboratory of Healthy Birth and Birth Defect Prevention in Western China, The First People's Hospital of Yunnan Province, Kunming, China.
Introduction: β-thalassemia is a genetic hemoglobinopathy characterized by defective β-globin synthesis and ineffective erythropoiesis. Pharmacological induction of fetal hemoglobin (HbF) via γ-globin gene activation represents a promising therapeutic strategy. Total ginsenosides (TG), the principal active constituents of , have shown epigenetic and transcriptional modulatory properties, yet their role in HbF induction remains unexplored.
View Article and Find Full Text PDFFunctions and Mechanisms of Diabetes-Linked Transcription Factors.
Front Biosci (Landmark Ed)
August 2025
School of Life Sciences, University of Technology Sydney, Ultimo, NSW 2007, Australia.
Transcription factors are significant regulators of gene expression in most biological processes related to diabetes, including beta cell (β-cell) development, insulin secretion and glucose metabolism. Dysregulation of transcription factor expression or abundance has been closely associated with the pathogenesis of type 1 and type 2 diabetes, including pancreatic and duodenal homeobox 1 (), neurogenic differentiation 1 (), and forkhead box protein O1 (). Gene expression is regulated at the transcriptional level by transcription factor binding, epigenetically by DNA methylation and chromatin remodelling, and post-transcriptional mechanisms, including alternative splicing and microRNA (miRNA).
View Article and Find Full Text PDFInvestigating the impact of hyperbilirubinemia on cognitive dysfunction in adult zebrafish: an in vivo model.
Korean J Anesthesiol
September 2025
Department of Anesthesiology and Pain Medicine, Korea University Ansan Hospital, Korea University College of Medicine, Ansan 15588, the Republic of Korea.
Background: Despite the well-known effects of elevated bilirubin in neonates, its neurotoxic potential in adults remains uncertain. In perioperative and hepatic disease contexts, transient bilirubin elevations are common; however, their direct contribution to cognitive dysfunction has not been clearly established. This study aimed to determine whether transient bilirubin elevation alone can impair cognition and disrupt blood-brain barrier (BBB) function in adult zebrafish, and to compare these effects with those of liver injury.
View Article and Find Full Text PDF