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To assess the image quality and radiation dose between reduced-dose CT with deep learning reconstruction (DLR) using SilverBeam filter and standard dose with iterative reconstruction (IR) in abdominopelvic CT. In total, 182 patients (mean age ± standard deviation, 63 ± 14 years; 100 men) were included. Standard-dose scanning was performed with a tube voltage of 100 kVp, automatic tube current modulation, and IR reconstruction, whereas reduced-dose scanning was performed with a tube voltage of 120 kVp, a SilverBeam filter, and DLR. Additionally, a contrast-enhanced (CE)-boost image was obtained for reduced-dose scanning. Radiation dose, objective, and subjective image analyses were performed in each body mass index (BMI) category. The radiation dose for SilverBeam with DLR was significantly lower than that of standard dose with IR, with an average reduction in the effective dose of 59.0% (1.87 vs. 4.57 mSv). Standard dose with IR (10.59 ± 1.75) and SilverBeam with DLR (10.60 ± 1.08) showed no significant difference in image noise (p = 0.99). In the obese group (BMI > 25 kg/m), there were no significant differences in SNRs of the liver, pancreas, and spleen between standard dose with IR and SilverBeam with DLR. SilverBeam with DLR + CE-boost demonstrated significantly better SNRs and CNRs, compared with standard dose with IR and SilverBeam with DLR. DLR combined with silver filter is effective for routine abdominopelvic CT, achieving a clearly reduced radiation dose while providing image quality that is non-inferior to standard dose with IR.
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http://dx.doi.org/10.1038/s41598-025-11184-7 | DOI Listing |
J Appl Clin Med Phys
September 2025
Clinical Imaging Physics Group, Duke University Health System, Durham, North Carolina, USA.
Introduction: Medical physicists play a critical role in ensuring image quality and patient safety, but their routine evaluations are limited in scope and frequency compared to the breadth of clinical imaging practices. An electronic radiologist feedback system can augment medical physics oversight for quality improvement. This work presents a novel quality feedback system integrated into the Epic electronic medical record (EMR) at a university hospital system, designed to facilitate feedback from radiologists to medical physicists and technologist leaders.
View Article and Find Full Text PDFClin Gastroenterol Hepatol
September 2025
Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Belgium. Electronic address:
Background And Aims: Infliximab and ustekinumab clearance have been suggested as predictors of disease activity in patients with inflammatory bowel diseases. We aimed to investigate the benefits of clearance monitoring for predicting endoscopic outcomes in patients with Crohn's disease (CD).
Methods: Data from patients with moderate-to-severe CD starting infliximab (n=108) and ustekinumab (n=80) therapy were repurposed.
Radiother Oncol
September 2025
Dept of Radiation Oncology, Centre Léon Bérard, Lyon, France. Electronic address:
Background And Purpose: To date, no consensus guidelines have been published that systematically guide delineation of primary and nodal Clinical Target Volumes (CTVs) in patients who require post-operative radiotherapy (PORT) for mucosal Head and Neck squamous cell carcinoma (HNSCC). As a result, significant individual, institutional and national variation exists in the way that CTVs are delineated in the post-operative setting, leading to considerable heterogeneity in radiotherapy treatment.
Methods: A multi-disciplinary group of experts convened by the European Society for Radiotherapy and Oncology (ESTRO) set-out principles for the multi-disciplinary management of oral cavity squamous cell carcinoma (OCSCC).
Environ Res
September 2025
Institute of Environmental Medicine and Integrative Health, Faculty of Medicine, University Hospital Augsburg, Augsburg, Germany; Institute of Environmental Medicine, Helmholtz Munich, Neuherberg, Germany. Electronic address:
Background: Currently, most researchers apply pollen extracts or -suspensions to assess the effects of pollen exposure on airway epithelia. How respiratory epithelia respond to pollen aerosols is not well studied because standardised methods to aerosolize pollen were not available until recently.
Aim Of Study: To develop and test a near-natural exposure model for pollen grains based on differentiated human nasal epithelial cells and a novel particle aerosoliser.
PLoS Med
September 2025
University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States of America.
Background: Oral emtricitabine/tenofovir disoproxil fumarate (F/TDF) preexposure prophylaxis (PrEP) effectiveness against HIV acquisition highly depends on adherence. For men who have sex with men, a dosing study in the United States (US) population defined clinically meaningful tenofovir diphosphate (TFV-DP) thresholds in dried blood spots (DBS) based on the rounded 25th percentile for 2, 4, and 7 doses/week as 350, 700, and 1,250 fmol/punch. However, divergent efficacy results in the first generation randomized clinical trials of F/TDF PrEP among African women led to several hypotheses to question whether the pharmacology and adherence requirement for oral F/TDF PrEP may be different in cisgender women compared to what is already established for men.
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