Optimizing Post-Acne Scar Treatment: A Pilot Comparative Study of Endo-Radiofrequency Subcision With and Without Platelet-Rich Plasma.

Introduction: Acne is a common disorder of the pilosebaceous unit, resulting from increased sebum secretion and the colonization of Propionibacterium. Scarring is the most common consequence of acne and can significantly affect patients' quality of life.

Methods: Patients with moderate to severe facial acne scars who were referred to the dermatology clinic in 2023 were enrolled. All patients underwent endo-radiofrequency subcision (Endo-RF subcision) on both sides of the face, with platelet-rich plasma (PRP) administered on one side only. Scarring was assessed using quantitative and qualitative measures based on the Goodman and Baron's global scarring grading system.

Results: Ten patients (eight females and two males) completed the study. Although qualitative scores improved in both groups, no statistically significant difference was observed. There was no significant correlation in the percentage of recovery between the two study groups (Endo-RF and PRP + Endo-RF) before and after treatment. Evaluations of the quantitative scores for both groups showed considerable improvements in the number of acne scars. A strongly significant correlation was observed in both groups compared to baseline. Although the combination therapy group showed greater improvement in quantitative scar scores from baseline, the difference was not statistically significant.

Conclusion: Both Endo-RF subcision and PRP combined with Endo-RF subcision are safe and effective modalities for treating post-acne scars. Although each method can improve acne scars, the combination therapy of Endo-RF with PRP may yield more desirable results.