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Background: Patients with Pierre Robin Sequence (PRS) treated with mandibular distraction (MD) frequently suffer from a cleft palate (CP). There are no standard practices surrounding the need for admission to a pediatric intensive care unit (PICU) following CP repair in these patients. This study will investigate the frequency of airway events following CP repair in this subset of patients.
Methods: A retrospective chart review of all patients with PRS treated with MD that also required CP repair surgery at the authors' institution from 2012 to 2022 was performed. Intraoperative and postoperative analgesic usage, preoperative and postoperative respiratory status, presence of a concomitant operation, comorbid anomalies, as well as age and weight at CP repair were recorded. Our primary outcomes included length of stay following CP repair, presence of airway events perioperatively/postoperatively, and admission status following CP repair.
Results: Twenty-nine patients underwent MD during this period, of which 13 patients also underwent repair of a CP. The average length of stay following CP repair was 2.3 days. Only 2 airway events were noted, and only 3 patients were admitted to the PICU following repair. Presence of comorbid musculoskeletal and neurologic abnormalities was associated with postoperative PICU admission.Remaining intubated following CP repair was associated with increased analgesic usage intraoperatively. A longer duration of intubation following MD was associated with PICU admission and remaining intubated following CP repair.
Conclusions: Overall, it appears that admission to the floor following CP repair in PRS patients with a history of MD is generally safe.
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ERJ Open Res
September 2025
Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain.
https://bit.ly/44jcdWz.
View Article and Find Full Text PDFZhonghua Jie He He Hu Xi Za Zhi
September 2025
Neuromuscular diseases are often accompanied by various types of sleep-related breathing disorders, which can exacerbate the underlying condition and are associated with a poor prognosis. Early identification is essential, and interventions such as non-invasive ventilation, oxygen therapy, and respiratory rehabilitation should be initiated promptly to mitigate disease progression and improve outcomes. Nevertheless, the rates of missed and misdiagnosed cases remain common in clinical practice.
View Article and Find Full Text PDFLaryngoscope
September 2025
UCSF Voice & Swallowing Center, Department of Otolaryngology-Head and Neck Surgery, University of California, San Francisco, California, USA.
Objectives: In patients with significant upper airway stenosis, airway compromise can occur associated with general anesthesia (GA). A previous study demonstrated the feasibility of awake laser laryngeal stenosis surgery (ALLSS) in the operating room (OR) in five patients. This study sought to determine patient outcomes of ALLSS.
View Article and Find Full Text PDFActa Anaesthesiol Scand
October 2025
Copenhagen Trial Unit, Centre for Clinical Intervention Research, The Capital Region, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.
Introduction: Electronic health records can be used to create high-quality databases if data are structured and well-registered, which is the case for most perioperative data in the Capital and Zealand Regions of Denmark. We present the purpose and development of the AI and Automation in Anaesthesia (TRIPLE-A) database-a platform designed for epidemiology, prediction, quality control, and automated research data collection.
Methods: Data collection from the electronic medical record (EPIC Systems Corporation, WI, USA) was approved by the Capital Region, Denmark, and ethical approval was waived.
Nat Sci Sleep
September 2025
Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, People's Republic of China.
Aim: Obstructive sleep apnea (OSA) is characterized by repetitive upper airway collapse during sleep, resulting in frequent cortical arousals. However, currently used frequency-based arousal metrics do not sufficiently capture the heterogeneity and clinical significance of arousal responses. The odds ratio product (ORP) is a novel electroencephalographic marker that provides a continuous assessment of sleep depth and has the potential to serve as an objective measure of arousal intensity.
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