Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Background: Violent injury survivors are at risk for revictimization. The St. Louis area hospital-based violence intervention program (HVIP), Life Outside of Violence (LOV), is the first multisystem, region-wide HVIP in the United States.
Objective: To describe the LOV program during its pilot phase and evaluate violent reinjury 1 year after index injury among LOV participants.
Design: Pilot observational cohort study of violently injured patients.
Setting: Data were queried from the program's multisystem data repository, which contains individual encounter-level data for all violent injury visits from the 2 adult and 2 pediatric LOV-partner level 1 trauma hospitals.
Participants: Patients eligible for LOV who were violently injured between 15 August 2018 and 31 December 2022 and enrolled in LOV, matched to control participants of nonenrolled LOV-eligible patients selected from the data repository using propensity score matching.
Intervention: Participation in the LOV program.
Measurements: Sociodemographic characteristics, predictors of LOV enrollment, and returning to a LOV partner hospital with a violent reinjury within 1 year of index injury. The probability of violent reinjury and 95% CIs were compared between LOV participants and control participants using Kaplan-Meier estimates.
Results: 233 of 3744 eligible patients enrolled in LOV. Of 198 LOV-enrolled participants matched to 388 nonenrolled control participants, Kaplan-Meier estimates for 1-year probability of reinjury were 7.6% (95% CI, 3.8% to 11.2%) among LOV participants and 7.4% (CI, 4.8% to 10.0%) in control participants.
Limitation: This pilot study cannot provide precise estimates of LOV intervention efficacy.
Conclusion: Although no informative evidence of differences in reinjury probability for LOV participants was seen, findings suggest that the overwhelming risk in which our patients are immersed cannot be overcome by an approach scaled for individual-level impact.
Primary Funding Source: Missouri Foundation for Health.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12379808 | PMC |
| http://dx.doi.org/10.7326/ANNALS-24-01576 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Abundance of Maternal Mitochondrial Genome Is Dispensable up to the Mitochondrial Genome Activation in Post-Implantation Embryos.
FASEB J
September 2025
Faculty of Medicine in Pilsen, Biomedical Center, Charles University, Prague, Czech Republic.
Mitochondria in the egg are suggested to be crucial for the onset of new life. However, there is ambiguous knowledge about the necessity for fertilization and early embryonic development. Therefore, we created a conditional Tfam knockout (Tfam; Zp3-Cre) to produce Tfam oocytes for investigation of the mitochondrial abundance in oocytes and early embryos.
View Article and Find Full Text PDFA vegetarian diet improves hepatic steatosis in MASLD patients through weight loss: a randomized controlled trial in China.
Food Funct
September 2025
School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
: The therapeutic potential of vegetarian diets in metabolic dysfunction-associated steatotic liver disease (MASLD) remains understudied in Asian populations. This randomized controlled trial aimed to evaluate the effects of a culturally adapted 6-month lacto-ovo-vegetarian diet (LOV-D) on hepatic steatosis and cardiometabolic risk factors through weight loss. : In this randomized trial, 220 Chinese adults with MASLD were assigned to LOV-D ( = 110) or an omnivore diet ( = 110) for 6 months.
View Article and Find Full Text PDFStaying at Work with Musculoskeletal Pain in a Physically Demanding Job: A Qualitative Exploration of Workers' and Managers' Perspectives.
J Occup Rehabil
September 2025
Center for Muscle and Joint Health, Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark.
Purpose: Staying at work despite recurrent or persistent musculoskeletal (MSK) pain offers mental and physical health benefits in addition to financial security for workers. This study explores worker and manager experiences and perspectives on stay-at-work practices to nuance our understanding of what drives successful or unsuccessful practices.
Methods: We conducted a vignette-based qualitative exploration of workplace practices of managers and workers from three medium-sized workplaces with physically demanding jobs.
Proximity-specific ribosome profiling reveals the logic of localized mitochondrial translation.
Cell
August 2025
Whitehead Institute for Biomedical Research, Cambridge, MA, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA; Howard Hughes Medical Institute
Localized translation broadly enables spatiotemporal control of gene expression. Here, we present LOV-domain-controlled ligase for translation localization (LOCL-TL), an optogenetic approach for monitoring translation with codon resolution at any defined subcellular location under physiological conditions. Application of LOCL-TL to mitochondrially localized translation revealed that ∼20% of human nuclear-encoded mitochondrial genes are translated on the outer mitochondrial membrane (OMM).
View Article and Find Full Text PDFPhototropin localization and interactions regulate photophysiological processes in Chlamydomonas reinhardtii.
Biochimie
August 2025
Laboratory of Optobiotechnology, School of Biotechnology, Jawaharlal Nehru University, New Delhi, 110067, India. Electronic address:
Phototropin, a blue-light sensing serine/threonine kinase, plays a pivotal role in regulating diverse photophysiological processes in both plants and algae. In Chlamydomonas reinhardtii, phototropin (CrPhot) localizes to the eyespot and flagella, coordinating key cellular functions such as phototaxis, photosynthesis, gametogenesis, and chlorophyll biosynthesis. Although prior studies have identified phototropin interactions with signaling proteins such as channelrhodopsins and light-harvesting complex proteins, its broader interaction network and regulatory mechanisms remain poorly understood.
View Article and Find Full Text PDF